Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research

Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like the 2002–2003 epidemic severe acute respiratory syndrome coronavirus (SARS-CoV), angiotensin converting enzyme-2 (ACE-2) has been identified as the SARS-CoV-2 receptor.(1–3) The vi...

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Autores principales: Abdul-Hafez, Amal, Mohamed, Tarek, Uhal, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373052/
https://www.ncbi.nlm.nih.gov/pubmed/34414260
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author Abdul-Hafez, Amal
Mohamed, Tarek
Uhal, Bruce D.
author_facet Abdul-Hafez, Amal
Mohamed, Tarek
Uhal, Bruce D.
author_sort Abdul-Hafez, Amal
collection PubMed
description Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like the 2002–2003 epidemic severe acute respiratory syndrome coronavirus (SARS-CoV), angiotensin converting enzyme-2 (ACE-2) has been identified as the SARS-CoV-2 receptor.(1–3) The virus docks into host cell via its spike protein binding to ACE-2 and undergoes proteolytic cleavage by TMPRSS2 protease to facilitate membrane fusion. The spike protein binding to ACE-2 has been shown to be stronger in the novel SARS-CoV-2 virus.(1) This review will present an overview of ACE-2 biology.
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spelling pubmed-83730522021-08-18 Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research Abdul-Hafez, Amal Mohamed, Tarek Uhal, Bruce D. J Lung Pulm Respir Res Article Coronavirus Disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like the 2002–2003 epidemic severe acute respiratory syndrome coronavirus (SARS-CoV), angiotensin converting enzyme-2 (ACE-2) has been identified as the SARS-CoV-2 receptor.(1–3) The virus docks into host cell via its spike protein binding to ACE-2 and undergoes proteolytic cleavage by TMPRSS2 protease to facilitate membrane fusion. The spike protein binding to ACE-2 has been shown to be stronger in the novel SARS-CoV-2 virus.(1) This review will present an overview of ACE-2 biology. 2021 2021-05-03 /pmc/articles/PMC8373052/ /pubmed/34414260 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and build upon your work non-commercially.
spellingShingle Article
Abdul-Hafez, Amal
Mohamed, Tarek
Uhal, Bruce D.
Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title_full Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title_fullStr Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title_full_unstemmed Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title_short Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research
title_sort angiotensin converting enzyme-2 (ace-2) role in disease and future in research
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373052/
https://www.ncbi.nlm.nih.gov/pubmed/34414260
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