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Coupling of the engineered DNA “mutator” to a biosensor as a new paradigm for activation of silent biosynthetic gene clusters in Streptomyces

DNA replication fidelity in Streptomyces bacteria, prolific producers of many medically important secondary metabolites, is understudied, while in Escherichia coli it is controlled by DnaQ, the ϵ subunit of DNA polymerase III (DNA PolIII). Manipulation of dnaQ paralogues in Streptomyces lividans TK2...

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Detalles Bibliográficos
Autores principales:	Sekurova, Olga N, Sun, Yi-Qian, Zehl, Martin, Rückert, Christian, Stich, Anna, Busche, Tobias, Kalinowski, Jörn, Zotchev, Sergey B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Synthetic Biology and Bioengineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373060/ https://www.ncbi.nlm.nih.gov/pubmed/34197612 http://dx.doi.org/10.1093/nar/gkab583

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