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Mutually exclusive substrate selection strategy by human m(3)C RNA transferases METTL2A and METTL6

tRNAs harbor the most diverse posttranscriptional modifications. The 3-methylcytidine (m(3)C) is widely distributed at position C32 (m(3)C32) of eukaryotic tRNA(Thr) and tRNA(Ser) species. m(3)C32 is decorated by the single methyltransferase Trm140 in budding yeasts; however, two (Trm140 and Trm141...

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Detalles Bibliográficos
Autores principales:	Mao, Xue-Ling, Li, Zi-Han, Huang, Meng-Han, Wang, Jin-Tao, Zhou, Jing-Bo, Li, Qing-Run, Xu, Hong, Wang, Xi-Jin, Zhou, Xiao-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373065/ https://www.ncbi.nlm.nih.gov/pubmed/34268557 http://dx.doi.org/10.1093/nar/gkab603

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