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Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover

The oxidative base damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is a highly mutagenic lesion because replicative DNA polymerases insert adenine (A) opposite 8-oxoG. In mammalian cells, the removal of A incorporated across from 8-oxoG is mediated by the glycosylase MUTYH during base excision repair (BER...

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Detalles Bibliográficos
Autores principales:	Jang, Sunbok, Schaich, Matthew A, Khuu, Cindy, Schnable, Brittani L, Majumdar, Chandrima, Watkins, Simon C, David, Sheila S, Van Houten, Bennett
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373069/ https://www.ncbi.nlm.nih.gov/pubmed/34232996 http://dx.doi.org/10.1093/nar/gkab591

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