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Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes
Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroenc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373111/ https://www.ncbi.nlm.nih.gov/pubmed/34155834 http://dx.doi.org/10.1002/advs.202100820 |
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author | Goswami, Debkalpa Domingo‐Lopez, Daniel A. Ward, Niamh A. Millman, Jeffrey R. Duffy, Garry P. Dolan, Eimear B. Roche, Ellen T. |
author_facet | Goswami, Debkalpa Domingo‐Lopez, Daniel A. Ward, Niamh A. Millman, Jeffrey R. Duffy, Garry P. Dolan, Eimear B. Roche, Ellen T. |
author_sort | Goswami, Debkalpa |
collection | PubMed |
description | Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem‐cell derived islets (SC‐islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed‐loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas. |
format | Online Article Text |
id | pubmed-8373111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83731112021-08-24 Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes Goswami, Debkalpa Domingo‐Lopez, Daniel A. Ward, Niamh A. Millman, Jeffrey R. Duffy, Garry P. Dolan, Eimear B. Roche, Ellen T. Adv Sci (Weinh) Reviews Stem cell derived insulin producing cells or islets have shown promise in reversing Type 1 Diabetes (T1D), yet successful transplantation currently necessitates long‐term modulation with immunosuppressant drugs. An alternative approach to avoiding this immune response is to utilize an islet macroencapsulation device, where islets are incorporated into a selectively permeable membrane that can protect the transplanted cells from acute host response, whilst enabling delivery of insulin. These macroencapsulation systems have to meet a number of stringent and challenging design criteria in order to achieve the ultimate goal of reversing T1D. In this progress report, the design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem‐cell derived islets (SC‐islets), highlighting distinct design parameters. Additionally, a perspective on the future for macroencapsulation systems is given, and how incorporating continuous sensing and closed‐loop feedback can be transformative in advancing toward an autonomous biohybrid artificial pancreas. John Wiley and Sons Inc. 2021-06-21 /pmc/articles/PMC8373111/ /pubmed/34155834 http://dx.doi.org/10.1002/advs.202100820 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Goswami, Debkalpa Domingo‐Lopez, Daniel A. Ward, Niamh A. Millman, Jeffrey R. Duffy, Garry P. Dolan, Eimear B. Roche, Ellen T. Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title_full | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title_fullStr | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title_full_unstemmed | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title_short | Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type 1 Diabetes |
title_sort | design considerations for macroencapsulation devices for stem cell derived islets for the treatment of type 1 diabetes |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373111/ https://www.ncbi.nlm.nih.gov/pubmed/34155834 http://dx.doi.org/10.1002/advs.202100820 |
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