Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption

Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). The drug ezetimibe inhibits NPC1L1-mediated absorption of cholesterol, lowering of circulating levels of low-density lipoprotein cholesterol. Here, we rep...

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Detalles Bibliográficos
Autores principales: Long, Tao, Liu, Yang, Qin, Yu, DeBose-Boyd, Russell A., Li, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373123/
https://www.ncbi.nlm.nih.gov/pubmed/34407950
http://dx.doi.org/10.1126/sciadv.abh3997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373123/
https://www.ncbi.nlm.nih.gov/pubmed/34407950
http://dx.doi.org/10.1126/sciadv.abh3997

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