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Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption

Polytopic Niemann-Pick C1-like 1 (NPC1L1) plays a major role in intestinal absorption of biliary cholesterol, vitamin E (VE), and vitamin K (VK). The drug ezetimibe inhibits NPC1L1-mediated absorption of cholesterol, lowering of circulating levels of low-density lipoprotein cholesterol. Here, we rep...

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Detalles Bibliográficos
Autores principales:	Long, Tao, Liu, Yang, Qin, Yu, DeBose-Boyd, Russell A., Li, Xiaochun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373123/ https://www.ncbi.nlm.nih.gov/pubmed/34407950 http://dx.doi.org/10.1126/sciadv.abh3997

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