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Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment

Many drugs show promising results in laboratory research but eventually fail clinical trials. We hypothesize that one main reason for this translational gap is that current cancer models are inadequate. Most models lack the tumor-stroma interactions, which are essential for proper representation of...

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Autores principales: Neufeld, Lena, Yeini, Eilam, Reisman, Noa, Shtilerman, Yael, Ben-Shushan, Dikla, Pozzi, Sabina, Madi, Asaf, Tiram, Galia, Eldar-Boock, Anat, Ferber, Shiran, Grossman, Rachel, Ram, Zvi, Satchi-Fainaro, Ronit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373143/
https://www.ncbi.nlm.nih.gov/pubmed/34407932
http://dx.doi.org/10.1126/sciadv.abi9119
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author Neufeld, Lena
Yeini, Eilam
Reisman, Noa
Shtilerman, Yael
Ben-Shushan, Dikla
Pozzi, Sabina
Madi, Asaf
Tiram, Galia
Eldar-Boock, Anat
Ferber, Shiran
Grossman, Rachel
Ram, Zvi
Satchi-Fainaro, Ronit
author_facet Neufeld, Lena
Yeini, Eilam
Reisman, Noa
Shtilerman, Yael
Ben-Shushan, Dikla
Pozzi, Sabina
Madi, Asaf
Tiram, Galia
Eldar-Boock, Anat
Ferber, Shiran
Grossman, Rachel
Ram, Zvi
Satchi-Fainaro, Ronit
author_sort Neufeld, Lena
collection PubMed
description Many drugs show promising results in laboratory research but eventually fail clinical trials. We hypothesize that one main reason for this translational gap is that current cancer models are inadequate. Most models lack the tumor-stroma interactions, which are essential for proper representation of cancer complexed biology. Therefore, we recapitulated the tumor heterogenic microenvironment by creating fibrin glioblastoma bioink consisting of patient-derived glioblastoma cells, astrocytes, and microglia. In addition, perfusable blood vessels were created using a sacrificial bioink coated with brain pericytes and endothelial cells. We observed similar growth curves, drug response, and genetic signature of glioblastoma cells grown in our 3D-bioink platform and in orthotopic cancer mouse models as opposed to 2D culture on rigid plastic plates. Our 3D-bioprinted model could be the basis for potentially replacing cell cultures and animal models as a powerful platform for rapid, reproducible, and robust target discovery; personalized therapy screening; and drug development.
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spelling pubmed-83731432021-08-27 Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment Neufeld, Lena Yeini, Eilam Reisman, Noa Shtilerman, Yael Ben-Shushan, Dikla Pozzi, Sabina Madi, Asaf Tiram, Galia Eldar-Boock, Anat Ferber, Shiran Grossman, Rachel Ram, Zvi Satchi-Fainaro, Ronit Sci Adv Research Articles Many drugs show promising results in laboratory research but eventually fail clinical trials. We hypothesize that one main reason for this translational gap is that current cancer models are inadequate. Most models lack the tumor-stroma interactions, which are essential for proper representation of cancer complexed biology. Therefore, we recapitulated the tumor heterogenic microenvironment by creating fibrin glioblastoma bioink consisting of patient-derived glioblastoma cells, astrocytes, and microglia. In addition, perfusable blood vessels were created using a sacrificial bioink coated with brain pericytes and endothelial cells. We observed similar growth curves, drug response, and genetic signature of glioblastoma cells grown in our 3D-bioink platform and in orthotopic cancer mouse models as opposed to 2D culture on rigid plastic plates. Our 3D-bioprinted model could be the basis for potentially replacing cell cultures and animal models as a powerful platform for rapid, reproducible, and robust target discovery; personalized therapy screening; and drug development. American Association for the Advancement of Science 2021-08-18 /pmc/articles/PMC8373143/ /pubmed/34407932 http://dx.doi.org/10.1126/sciadv.abi9119 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Research Articles
Neufeld, Lena
Yeini, Eilam
Reisman, Noa
Shtilerman, Yael
Ben-Shushan, Dikla
Pozzi, Sabina
Madi, Asaf
Tiram, Galia
Eldar-Boock, Anat
Ferber, Shiran
Grossman, Rachel
Ram, Zvi
Satchi-Fainaro, Ronit
Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title_full Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title_fullStr Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title_full_unstemmed Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title_short Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
title_sort microengineered perfusable 3d-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373143/
https://www.ncbi.nlm.nih.gov/pubmed/34407932
http://dx.doi.org/10.1126/sciadv.abi9119
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