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Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes

Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of patients with T2D are underweight or have normal weight. Several studies have linked the gut microbiome to obesity and T2D, but the role of gut microbiota in lean individuals with T2D having unique clinical cha...

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Autores principales: Zhang, Jing, Ni, Yueqiong, Qian, Lingling, Fang, Qichen, Zheng, Tingting, Zhang, Mingliang, Gao, Qiongmei, Zhang, Ying, Ni, Jiacheng, Hou, Xuhong, Bao, Yuqian, Kovatcheva‐Datchary, Petia, Xu, Aimin, Li, Huating, Panagiotou, Gianni, Jia, Weiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373164/
https://www.ncbi.nlm.nih.gov/pubmed/34085773
http://dx.doi.org/10.1002/advs.202100536
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author Zhang, Jing
Ni, Yueqiong
Qian, Lingling
Fang, Qichen
Zheng, Tingting
Zhang, Mingliang
Gao, Qiongmei
Zhang, Ying
Ni, Jiacheng
Hou, Xuhong
Bao, Yuqian
Kovatcheva‐Datchary, Petia
Xu, Aimin
Li, Huating
Panagiotou, Gianni
Jia, Weiping
author_facet Zhang, Jing
Ni, Yueqiong
Qian, Lingling
Fang, Qichen
Zheng, Tingting
Zhang, Mingliang
Gao, Qiongmei
Zhang, Ying
Ni, Jiacheng
Hou, Xuhong
Bao, Yuqian
Kovatcheva‐Datchary, Petia
Xu, Aimin
Li, Huating
Panagiotou, Gianni
Jia, Weiping
author_sort Zhang, Jing
collection PubMed
description Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of patients with T2D are underweight or have normal weight. Several studies have linked the gut microbiome to obesity and T2D, but the role of gut microbiota in lean individuals with T2D having unique clinical characteristics remains unclear. A metagenomic and targeted metabolomic analysis is conducted in 182 lean and abdominally obese individuals with and without newly diagnosed T2D. The abundance of Akkermansia muciniphila (A. muciniphila) significantly decreases in lean individuals with T2D than without T2D, but not in the comparison of obese individuals with and without T2D. Its abundance correlates inversely with serum 3β‐chenodeoxycholic acid (βCDCA) levels and positively with insulin secretion and fibroblast growth factor 15/19 (FGF15/19) concentrations. The supplementation with A. muciniphila is sufficient to protect mice against high sucrose‐induced impairment of glucose intolerance by decreasing βCDCA and increasing insulin secretion and FGF15/19. Furthermore, βCDCA inhibits insulin secretion and FGF15/19 expression. These findings suggest that decreased abundance of A. muciniphila is linked to the impairment of insulin secretion and glucose homeostasis in lean T2D, paving the way for new therapeutic options for the prevention or treatment of diabetes.
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spelling pubmed-83731642021-08-24 Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes Zhang, Jing Ni, Yueqiong Qian, Lingling Fang, Qichen Zheng, Tingting Zhang, Mingliang Gao, Qiongmei Zhang, Ying Ni, Jiacheng Hou, Xuhong Bao, Yuqian Kovatcheva‐Datchary, Petia Xu, Aimin Li, Huating Panagiotou, Gianni Jia, Weiping Adv Sci (Weinh) Research Articles Although obesity occurs in most of the patients with type 2 diabetes (T2D), a fraction of patients with T2D are underweight or have normal weight. Several studies have linked the gut microbiome to obesity and T2D, but the role of gut microbiota in lean individuals with T2D having unique clinical characteristics remains unclear. A metagenomic and targeted metabolomic analysis is conducted in 182 lean and abdominally obese individuals with and without newly diagnosed T2D. The abundance of Akkermansia muciniphila (A. muciniphila) significantly decreases in lean individuals with T2D than without T2D, but not in the comparison of obese individuals with and without T2D. Its abundance correlates inversely with serum 3β‐chenodeoxycholic acid (βCDCA) levels and positively with insulin secretion and fibroblast growth factor 15/19 (FGF15/19) concentrations. The supplementation with A. muciniphila is sufficient to protect mice against high sucrose‐induced impairment of glucose intolerance by decreasing βCDCA and increasing insulin secretion and FGF15/19. Furthermore, βCDCA inhibits insulin secretion and FGF15/19 expression. These findings suggest that decreased abundance of A. muciniphila is linked to the impairment of insulin secretion and glucose homeostasis in lean T2D, paving the way for new therapeutic options for the prevention or treatment of diabetes. John Wiley and Sons Inc. 2021-06-04 /pmc/articles/PMC8373164/ /pubmed/34085773 http://dx.doi.org/10.1002/advs.202100536 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Zhang, Jing
Ni, Yueqiong
Qian, Lingling
Fang, Qichen
Zheng, Tingting
Zhang, Mingliang
Gao, Qiongmei
Zhang, Ying
Ni, Jiacheng
Hou, Xuhong
Bao, Yuqian
Kovatcheva‐Datchary, Petia
Xu, Aimin
Li, Huating
Panagiotou, Gianni
Jia, Weiping
Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title_full Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title_fullStr Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title_full_unstemmed Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title_short Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes
title_sort decreased abundance of akkermansia muciniphila leads to the impairment of insulin secretion and glucose homeostasis in lean type 2 diabetes
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373164/
https://www.ncbi.nlm.nih.gov/pubmed/34085773
http://dx.doi.org/10.1002/advs.202100536
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