V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity

The current pandemic of COVID-19 is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 spike protein receptor-binding domain (RBD) is the critical determinant of viral tropism and infectivity. To investigate whether naturally occurring RBD mut...

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Detalles Bibliográficos
Autores principales: Ou, Junxian, Zhou, Zhonghua, Dai, Ruixue, Zhang, Jing, Zhao, Shan, Wu, Xiaowei, Lan, Wendong, Ren, Yi, Cui, Lilian, Lan, Qiaoshuai, Lu, Lu, Seto, Donald, Chodosh, James, Wu, Jianguo, Zhang, Gong, Zhang, Qiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Virus-Cell Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373230/
https://www.ncbi.nlm.nih.gov/pubmed/34105996
http://dx.doi.org/10.1128/JVI.00617-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373230/
https://www.ncbi.nlm.nih.gov/pubmed/34105996
http://dx.doi.org/10.1128/JVI.00617-21

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