Down‐regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer

BACKGROUND: Gastric cancer (GC) is a common cancer. Circular RNAs (circRNAs) regulate the pathogenesis of GC. This study aims to explore its potential as a GC biomarker. METHODS: The expression of hsa_circ_0006470 in GC tissues and GC cell lines was measured by quantitative reverse transcription‐pol...

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Detalles Bibliográficos
Autores principales: Yao, Lipeng, Xie, Yaoyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373341/
https://www.ncbi.nlm.nih.gov/pubmed/34165822
http://dx.doi.org/10.1002/jcla.23879
Descripción
Sumario:BACKGROUND: Gastric cancer (GC) is a common cancer. Circular RNAs (circRNAs) regulate the pathogenesis of GC. This study aims to explore its potential as a GC biomarker. METHODS: The expression of hsa_circ_0006470 in GC tissues and GC cell lines was measured by quantitative reverse transcription‐polymerase chain reaction. The diagnostic value of hsa_circ_0006470 was estimated by the receiver operating characteristic (ROC) curve. RESULTS: Compared with adjacent normal tissues, the expression of hsa_circ_0006470 in GC tissues was significantly lower. The expression levels of hsa_circ_0006470 in different TNM stages and different invasion degrees were significantly different. The area under the ROC curve was 0.783, with sensitivity and specificity 0.725 and 0.750, respectively. CONCLUSIONS: Hsa_circ_0006470 has a high value as a diagnostic biomarker for GC.

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