Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis

BACKGROUND: Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden cardiac death (SCD) risk. While the genetics of arrhythmia syndromes have been studied, relations between electrocardiographic intervals and rare genetic variation at a population level a...

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Detalles Bibliográficos
Autores principales: Choi, Seung Hoan, Jurgens, Sean J., Haggerty, Christopher M., Hall, Amelia W., Halford, Jennifer L., Morrill, Valerie N., Weng, Lu-Chen, Lagerman, Braxton, Mirshahi, Tooraj, Pettinger, Mary, Guo, Xiuqing, Lin, Henry J., Alonso, Alvaro, Soliman, Elsayed Z., Kornej, Jelena, Lin, Honghuang, Moscati, Arden, Nadkarni, Girish N., Brody, Jennifer A., Wiggins, Kerri L., Cade, Brian E., Lee, Jiwon, Austin-Tse, Christina, Blackwell, Tom, Chaffin, Mark D., Lee, Christina J.-Y., Rehm, Heidi L., Roselli, Carolina, Redline, Susan, Mitchell, Braxton D., Sotoodehnia, Nona, Psaty, Bruce M., Heckbert, Susan R., Loos, Ruth J.F., Vasan, Ramachandran S., Benjamin, Emelia J., Correa, Adolfo, Boerwinkle, Eric, Arking, Dan E., Rotter, Jerome I., Rich, Stephen S., Whitsel, Eric A., Perez, Marco, Kooperberg, Charles, Fornwalt, Brandon K., Lunetta, Kathryn L., Ellinor, Patrick T., Lubitz, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373440/
https://www.ncbi.nlm.nih.gov/pubmed/34319147
http://dx.doi.org/10.1161/CIRCGEN.120.003300

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