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Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges
Stable aneuploid genomes with nonrandom numerical changes in uneven ploidy ranges define distinct subsets of hematologic malignancies and solid tumors. The idea put forward herein suggests that they emerge from interactions between diploid mitotic and G0/G1 cells, which can in a single step produce...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373647/ https://www.ncbi.nlm.nih.gov/pubmed/34422788 http://dx.doi.org/10.3389/fcell.2021.631946 |
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author | Haas, Oskar A. |
author_facet | Haas, Oskar A. |
author_sort | Haas, Oskar A. |
collection | PubMed |
description | Stable aneuploid genomes with nonrandom numerical changes in uneven ploidy ranges define distinct subsets of hematologic malignancies and solid tumors. The idea put forward herein suggests that they emerge from interactions between diploid mitotic and G0/G1 cells, which can in a single step produce all combinations of mono-, di-, tri-, tetra- and pentasomic paternal/maternal homologue configurations that define such genomes. A nanotube-mediated influx of interphase cell cytoplasm into mitotic cells would thus be responsible for the critical nondisjunction and segregation errors by physically impeding the proper formation of the cell division machinery, whereas only a complete cell fusion can simultaneously generate pentasomies, uniparental trisomies as well as biclonal hypo- and hyperdiploid cell populations. The term “somatic sex” was devised to accentuate the similarities between germ cell and somatic cell fusions. A somatic cell fusion, in particular, recapitulates many processes that are also instrumental in the formation of an abnormal zygote that involves a diploid oocyte and a haploid sperm, which then may further develop into a digynic triploid embryo. Despite their somehow deceptive differences and consequences, the resemblance of these two routes may go far beyond of what has hitherto been appreciated. Based on the arguments put forward herein, I propose that embryonic malignancies of mesenchymal origin with these particular types of aneuploidies can thus be viewed as the kind of flawed somatic equivalent of a digynic triploid embryo. |
format | Online Article Text |
id | pubmed-8373647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83736472021-08-20 Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges Haas, Oskar A. Front Cell Dev Biol Cell and Developmental Biology Stable aneuploid genomes with nonrandom numerical changes in uneven ploidy ranges define distinct subsets of hematologic malignancies and solid tumors. The idea put forward herein suggests that they emerge from interactions between diploid mitotic and G0/G1 cells, which can in a single step produce all combinations of mono-, di-, tri-, tetra- and pentasomic paternal/maternal homologue configurations that define such genomes. A nanotube-mediated influx of interphase cell cytoplasm into mitotic cells would thus be responsible for the critical nondisjunction and segregation errors by physically impeding the proper formation of the cell division machinery, whereas only a complete cell fusion can simultaneously generate pentasomies, uniparental trisomies as well as biclonal hypo- and hyperdiploid cell populations. The term “somatic sex” was devised to accentuate the similarities between germ cell and somatic cell fusions. A somatic cell fusion, in particular, recapitulates many processes that are also instrumental in the formation of an abnormal zygote that involves a diploid oocyte and a haploid sperm, which then may further develop into a digynic triploid embryo. Despite their somehow deceptive differences and consequences, the resemblance of these two routes may go far beyond of what has hitherto been appreciated. Based on the arguments put forward herein, I propose that embryonic malignancies of mesenchymal origin with these particular types of aneuploidies can thus be viewed as the kind of flawed somatic equivalent of a digynic triploid embryo. Frontiers Media S.A. 2021-08-04 /pmc/articles/PMC8373647/ /pubmed/34422788 http://dx.doi.org/10.3389/fcell.2021.631946 Text en Copyright © 2021 Haas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Haas, Oskar A. Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title | Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title_full | Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title_fullStr | Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title_full_unstemmed | Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title_short | Somatic Sex: On the Origin of Neoplasms With Chromosome Counts in Uneven Ploidy Ranges |
title_sort | somatic sex: on the origin of neoplasms with chromosome counts in uneven ploidy ranges |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373647/ https://www.ncbi.nlm.nih.gov/pubmed/34422788 http://dx.doi.org/10.3389/fcell.2021.631946 |
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