CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis

Basal-like breast cancers (BLBC) are characterized by defects in homologous recombination (HR), deficient mitotic checkpoint, and high-proliferation activity. Here, we discover CIP2A as a candidate driver of BLBC. CIP2A was essential for DNA damage–induced initiation of mouse BLBC-like mammary tumor...

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Detalles Bibliográficos
Autores principales: Laine, Anni, Nagelli, Srikar G., Farrington, Caroline, Butt, Umar, Cvrljevic, Anna N., Vainonen, Julia P., Feringa, Femke M., Grönroos, Tove J., Gautam, Prson, Khan, Sofia, Sihto, Harri, Qiao, Xi, Pavic, Karolina, Connolly, Denise C., Kronqvist, Pauliina, Elo, Laura L., Maurer, Jochen, Wennerberg, Krister, Medema, Rene H., Joensuu, Heikki, Peuhu, Emilia, de Visser, Karin, Narla, Goutham, Westermarck, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Tumor Biology and Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373817/
https://www.ncbi.nlm.nih.gov/pubmed/34145035
http://dx.doi.org/10.1158/0008-5472.CAN-20-3651

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