Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021

In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vaccination status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, controlling for previous infections, household-exposure and temporal trends. We included 301,741...

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Detalles Bibliográficos
Autores principales: Braeye, Toon, Cornelissen, Laura, Catteau, Lucy, Haarhuis, Freek, Proesmans, Kristiaan, De Ridder, Karin, Djiena, Achille, Mahieu, Romain, De Leeuw, Frances, Dreuw, Alex, Hammami, Naima, Quoilin, Sophie, Van Oyen, Herman, Wyndham-Thomas, Chloé, Van Cauteren, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373820/
https://www.ncbi.nlm.nih.gov/pubmed/34454789
http://dx.doi.org/10.1016/j.vaccine.2021.08.060
Descripción
Sumario:In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vaccination status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, controlling for previous infections, household-exposure and temporal trends. We included 301,741 tests from 25 January to 24 June 2021. Full-schedule vaccination was associated with significant protection against infection. In addition, mRNA-vaccines reduced onward transmission: VE-estimates increased to >90% when index and contact were fully vaccinated. The small number of viral-vector vaccines included limited interpretability.

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