Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021

In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vaccination status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, controlling for previous infections, household-exposure and temporal trends. We included 301,741...

Descripción completa

Detalles Bibliográficos
Autores principales: Braeye, Toon, Cornelissen, Laura, Catteau, Lucy, Haarhuis, Freek, Proesmans, Kristiaan, De Ridder, Karin, Djiena, Achille, Mahieu, Romain, De Leeuw, Frances, Dreuw, Alex, Hammami, Naima, Quoilin, Sophie, Van Oyen, Herman, Wyndham-Thomas, Chloé, Van Cauteren, Dieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373820/
https://www.ncbi.nlm.nih.gov/pubmed/34454789
http://dx.doi.org/10.1016/j.vaccine.2021.08.060
_version_ 1783739984669310976
author Braeye, Toon
Cornelissen, Laura
Catteau, Lucy
Haarhuis, Freek
Proesmans, Kristiaan
De Ridder, Karin
Djiena, Achille
Mahieu, Romain
De Leeuw, Frances
Dreuw, Alex
Hammami, Naima
Quoilin, Sophie
Van Oyen, Herman
Wyndham-Thomas, Chloé
Van Cauteren, Dieter
author_facet Braeye, Toon
Cornelissen, Laura
Catteau, Lucy
Haarhuis, Freek
Proesmans, Kristiaan
De Ridder, Karin
Djiena, Achille
Mahieu, Romain
De Leeuw, Frances
Dreuw, Alex
Hammami, Naima
Quoilin, Sophie
Van Oyen, Herman
Wyndham-Thomas, Chloé
Van Cauteren, Dieter
author_sort Braeye, Toon
collection PubMed
description In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vaccination status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, controlling for previous infections, household-exposure and temporal trends. We included 301,741 tests from 25 January to 24 June 2021. Full-schedule vaccination was associated with significant protection against infection. In addition, mRNA-vaccines reduced onward transmission: VE-estimates increased to >90% when index and contact were fully vaccinated. The small number of viral-vector vaccines included limited interpretability.
format Online
Article
Text
id pubmed-8373820
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher The Author(s). Published by Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-83738202021-08-19 Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021 Braeye, Toon Cornelissen, Laura Catteau, Lucy Haarhuis, Freek Proesmans, Kristiaan De Ridder, Karin Djiena, Achille Mahieu, Romain De Leeuw, Frances Dreuw, Alex Hammami, Naima Quoilin, Sophie Van Oyen, Herman Wyndham-Thomas, Chloé Van Cauteren, Dieter Vaccine Short Communication In Belgium, high-risk contacts of an infected person were offered PCR-testing irrespective of their vaccination status. We estimated vaccine effectiveness (VE) against infection and onwards transmission, controlling for previous infections, household-exposure and temporal trends. We included 301,741 tests from 25 January to 24 June 2021. Full-schedule vaccination was associated with significant protection against infection. In addition, mRNA-vaccines reduced onward transmission: VE-estimates increased to >90% when index and contact were fully vaccinated. The small number of viral-vector vaccines included limited interpretability. The Author(s). Published by Elsevier Ltd. 2021-09-15 2021-08-19 /pmc/articles/PMC8373820/ /pubmed/34454789 http://dx.doi.org/10.1016/j.vaccine.2021.08.060 Text en © 2021 The Author(s) Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Short Communication
Braeye, Toon
Cornelissen, Laura
Catteau, Lucy
Haarhuis, Freek
Proesmans, Kristiaan
De Ridder, Karin
Djiena, Achille
Mahieu, Romain
De Leeuw, Frances
Dreuw, Alex
Hammami, Naima
Quoilin, Sophie
Van Oyen, Herman
Wyndham-Thomas, Chloé
Van Cauteren, Dieter
Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title_full Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title_fullStr Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title_full_unstemmed Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title_short Vaccine effectiveness against infection and onwards transmission of COVID-19: Analysis of Belgian contact tracing data, January-June 2021
title_sort vaccine effectiveness against infection and onwards transmission of covid-19: analysis of belgian contact tracing data, january-june 2021
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373820/
https://www.ncbi.nlm.nih.gov/pubmed/34454789
http://dx.doi.org/10.1016/j.vaccine.2021.08.060
work_keys_str_mv AT braeyetoon vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT cornelissenlaura vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT catteaulucy vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT haarhuisfreek vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT proesmanskristiaan vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT deridderkarin vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT djienaachille vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT mahieuromain vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT deleeuwfrances vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT dreuwalex vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT hammaminaima vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT quoilinsophie vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT vanoyenherman vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT wyndhamthomaschloe vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021
AT vancauterendieter vaccineeffectivenessagainstinfectionandonwardstransmissionofcovid19analysisofbelgiancontacttracingdatajanuaryjune2021

Ejemplares similares