Cargando…

The interferon landscape along the respiratory tract impacts the severity of COVID-19

Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sposito, Benedetta, Broggi, Achille, Pandolfi, Laura, Crotta, Stefania, Clementi, Nicola, Ferrarese, Roberto, Sisti, Sofia, Criscuolo, Elena, Spreafico, Roberto, Long, Jaclyn M., Ambrosi, Alessandro, Liu, Enju, Frangipane, Vanessa, Saracino, Laura, Bozzini, Sara, Marongiu, Laura, Facchini, Fabio A., Bottazzi, Andrea, Fossali, Tommaso, Colombo, Riccardo, Clementi, Massimo, Tagliabue, Elena, Chou, Janet, Pontiroli, Antonio E., Meloni, Federica, Wack, Andreas, Mancini, Nicasio, Zanoni, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373821/ https://www.ncbi.nlm.nih.gov/pubmed/34492226 http://dx.doi.org/10.1016/j.cell.2021.08.016

Ejemplares similares

Severity of SARS-CoV-2 infection as a function of the interferon landscape across the respiratory tract of COVID-19 patients.
por: Sposito, Benedetta, et al.
Publicado: (2021)

Proper Selection of In Vitro Cell Model Affects the Characterization of the Neutralizing Antibody Response against SARS-CoV-2
por: Criscuolo, Elena, et al.
Publicado: (2022)

Combined Prophylactic and Therapeutic Use Maximizes Hydroxychloroquine Anti-SARS-CoV-2 Effects in vitro
por: Clementi, Nicola, et al.
Publicado: (2020)

Fast inactivation of SARS-CoV-2 by UV-C and ozone exposure on different materials
por: Criscuolo, Elena, et al.
Publicado: (2021)

Influenza B-cells Protective Epitope Characterization: A Passkey for the Rational Design of New Broad-Range Anti-Influenza Vaccines
por: Clementi, Nicola, et al.
Publicado: (2012)

Type III interferons disrupt the lung epithelial barrier upon viral recognition
por: Broggi, Achille, et al.
Publicado: (2020)

Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?
por: Nicasio, Mancini, et al.
Publicado: (2012)

Viral Respiratory Pathogens and Lung Injury
por: Clementi, Nicola, et al.
Publicado: (2021)

JC Polyomavirus (JCV) and Monoclonal Antibodies: Friends or Potential Foes?
por: Diotti, Roberta Antonia, et al.
Publicado: (2013)

Dual-Domain Reporter Approach for Multiplex Identification of Major SARS-CoV-2 Variants of Concern in a Microarray-Based Assay
por: Damin, Francesco, et al.
Publicado: (2023)

Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens
por: Clementi, Nicola, et al.
Publicado: (2012)

Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy
por: Castelli, Matteo, et al.
Publicado: (2021)

Differential Composition of Vaginal Microbiome, but Not of Seminal Microbiome, Is Associated With Successful Intrauterine Insemination in Couples With Idiopathic Infertility: A Prospective Observational Study
por: Amato, Virginia, et al.
Publicado: (2019)

A closer look at prion strains: Characterization and important implications
por: Solforosi, Laura, et al.
Publicado: (2013)

A Human Stem Cell-Derived Neurosensory–Epithelial Circuitry on a Chip to Model Herpes Simplex Virus Reactivation
por: Mazzara, Pietro Giuseppe, et al.
Publicado: (2022)

IL-1 and IL-6 inhibition affects the neutralising activity of anti-SARS-CoV-2 antibodies in patients with COVID-19
por: Della-Torre, Emanuel, et al.
Publicado: (2021)

Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine
por: Ferrari, Davide, et al.
Publicado: (2021)

HCV Proteins and Immunoglobulin Variable Gene (IgV) Subfamilies in HCV-Induced Type II Mixed Cryoglobulinemia: A Concurrent Pathogenetic Role
por: Sautto, Giuseppe, et al.
Publicado: (2012)

Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols
por: Caputo, Valeria, et al.
Publicado: (2020)

Molecular Signatures of Hepatitis C Virus (HCV)-Induced Type II Mixed Cryoglobulinemia (MCII)
por: Sautto, Giuseppe, et al.
Publicado: (2012)

Naringenin is a powerful inhibitor of SARS-CoV-2 infection in vitro
por: Clementi, Nicola, et al.
Publicado: (2021)

Maturation signatures of conventional dendritic cell subtypes in COVID‐19 suggest direct viral sensing
por: Marongiu, Laura, et al.
Publicado: (2021)

Possible Future Monoclonal Antibody (mAb)-Based Therapy against Arbovirus Infections
por: Sautto, Giuseppe, et al.
Publicado: (2013)

Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome
por: Giambruno, Roberto, et al.
Publicado: (2023)

A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
por: De Marco, Donata, et al.
Publicado: (2012)

Adaptive immunity against gut microbiota enhances apoE-mediated immune regulation and reduces atherosclerosis and western-diet-related inflammation
por: Saita, Diego, et al.
Publicado: (2016)

Therapeutic Use of Intranasal Glucagon: Resolution of Hypoglycemia
por: Pontiroli, Antonio E., et al.
Publicado: (2019)

A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes
por: Clementi, Nicola, et al.
Publicado: (2011)

Chimeric antigen receptor (CAR)-engineered T cells redirected against hepatitis C virus (HCV) E2 glycoprotein
por: Sautto, Giuseppe A, et al.
Publicado: (2016)

SARS-CoV-2 infection despite high levels of vaccine-induced anti-Receptor-Binding-Domain antibodies: a study on 1110 health-care professionals from a northern Italian university hospital
por: Ferrari, Davide, et al.
Publicado: (2022)

Hepatitis C Virus (HCV) Infection May Elicit Neutralizing Antibodies Targeting Epitopes Conserved in All Viral Genotypes
por: Mancini, Nicasio, et al.
Publicado: (2009)

A Biologically-validated HCV E1E2 Heterodimer Structural Model
por: Castelli, Matteo, et al.
Publicado: (2017)

Broncho-alveolar inflammation in COVID-19 patients: a correlation with clinical outcome
por: Pandolfi, Laura, et al.
Publicado: (2020)

Structural and Antigenic Definition of Hepatitis C Virus E2 Glycoprotein Epitopes Targeted by Monoclonal Antibodies
por: Sautto, Giuseppe, et al.
Publicado: (2013)

Use of glucagon in severe hypoglycemia is scarce in most countries, and has not been expanded by new ready-to-use glucagons
por: Pontiroli, Antonio E., et al.
Publicado: (2022)

Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection
por: Severa, Martina, et al.
Publicado: (2021)

Neutrophil Extracellular Traps Induce the Epithelial-Mesenchymal Transition: Implications in Post-COVID-19 Fibrosis
por: Pandolfi, Laura, et al.
Publicado: (2021)

Anti-HIV-1 Response Elicited in Rabbits by Anti-Idiotype Monoclonal Antibodies Mimicking the CD4-Binding Site
por: Burioni, Roberto, et al.
Publicado: (2008)

Dose-Dependent Impairment of the Immune Response to the Moderna-1273 mRNA Vaccine by Mycophenolate Mofetil in Patients with Rheumatic and Autoimmune Liver Diseases
por: De Santis, Maria, et al.
Publicado: (2022)

Mechanisms of Hepatitis C Virus Escape from Vaccine-Relevant Neutralizing Antibodies
por: Velázquez-Moctezuma, Rodrigo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ahutanu05nltmt94h21kchhli0