α-Synuclein-induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability

Pathophysiological damages and loss of function of dopamine neurons precede their demise and contribute to the early phases of Parkinson’s disease. The presence of aberrant intracellular pathological inclusions of the protein α-synuclein within ventral midbrain dopaminergic neurons is one of the car...

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Detalles Bibliográficos
Autores principales: Dagra, Abeer, Miller, Douglas R., Lin, Min, Gopinath, Adithya, Shaerzadeh, Fatemeh, Harris, Sharonda, Sorrentino, Zachary A., Støier, Jonatan Fullerton, Velasco, Sophia, Azar, Janelle, Alonge, Adetola R., Lebowitz, Joseph J., Ulm, Brittany, Bu, Mengfei, Hansen, Carissa A., Urs, Nikhil, Giasson, Benoit I., Khoshbouei, Habibeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373893/
https://www.ncbi.nlm.nih.gov/pubmed/34408150
http://dx.doi.org/10.1038/s41531-021-00210-w

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