PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Poly(ADP)-ribosylation (PARylation) regulates chromatin structure and recruits DNA repair proteins. Using single-molecule fluorescence microscopy to track topoisomerase I (TOP1) in live cells, we found that sustained PARylation blocked the repair of TOP1 DNA-protein crosslinks (TOP1-DPCs) in a simil...

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Detalles Bibliográficos
Autores principales: Sun, Yilun, Chen, Jiji, Huang, Shar-yin N., Su, Yijun P., Wang, Wenjie, Agama, Keli, Saha, Sourav, Jenkins, Lisa M., Pascal, John M., Pommier, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373905/
https://www.ncbi.nlm.nih.gov/pubmed/34408146
http://dx.doi.org/10.1038/s41467-021-25252-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373905/
https://www.ncbi.nlm.nih.gov/pubmed/34408146
http://dx.doi.org/10.1038/s41467-021-25252-9

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