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New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery

Stroke remains the leading cause of long-term disability worldwide with significant long-term sequelae. However, there is no highly effective treatment to enhance post-stroke recovery despite extensive efforts in exploring rehabilitative therapies. Neurorehabilitation is recognized as the cornerston...

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Autores principales: Yu, Fang, Huang, Tingting, Ran, Yuanyuan, Li, Da, Ye, Lin, Tian, Guiqin, Xi, Jianing, Liu, Zongjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374071/
https://www.ncbi.nlm.nih.gov/pubmed/34421544
http://dx.doi.org/10.3389/fncel.2021.727899
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author Yu, Fang
Huang, Tingting
Ran, Yuanyuan
Li, Da
Ye, Lin
Tian, Guiqin
Xi, Jianing
Liu, Zongjian
author_facet Yu, Fang
Huang, Tingting
Ran, Yuanyuan
Li, Da
Ye, Lin
Tian, Guiqin
Xi, Jianing
Liu, Zongjian
author_sort Yu, Fang
collection PubMed
description Stroke remains the leading cause of long-term disability worldwide with significant long-term sequelae. However, there is no highly effective treatment to enhance post-stroke recovery despite extensive efforts in exploring rehabilitative therapies. Neurorehabilitation is recognized as the cornerstone of functional restoration therapy in stroke, where treatments are focused on neuroplastic regulation to reverse neural structural disruption and improve neurofunctional networks. Post-stroke neuroplasticity changes begin within hours of symptom onset and reaches a plateau by 3 to 4 weeks within the global brain in animal studies. It plays a determining role in spontaneous stroke recovery. Microglia are immediately activated following cerebral ischemia, which has been found both proximal to the primary ischemic injury and at the remote brain regions which have functional connections to the primary injury area. Microglia exhibit different activation profiles based on the microenvironment and adaptively switch their phenotypes in a spatiotemporal manner in response to brain injuries. Microglial activation coincides with neuroplasticity after stroke, which provides the fundamental base for the microglia-mediated inflammatory responses involved in the entire neural network rewiring and brain repair. Microglial activation exerts important effects on spontaneous recovery after stroke, including structural and functional reestablishment of neurovascular networks, neurogenesis, axonal remodeling, and blood vessel regeneration. In this review, we focus on the crosstalk between microglial activation and endogenous neuroplasticity, with a special focus on the plastic alterations in the whole brain network and their implications for structural and functional restoration after stroke. We then summarize recent advances in the impacts of microglial phenotype polarization on brain plasticity, trying to discuss the potential efficacy of microglia-based extrinsic restorative interventions in promoting post-stroke recovery.
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spelling pubmed-83740712021-08-20 New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery Yu, Fang Huang, Tingting Ran, Yuanyuan Li, Da Ye, Lin Tian, Guiqin Xi, Jianing Liu, Zongjian Front Cell Neurosci Neuroscience Stroke remains the leading cause of long-term disability worldwide with significant long-term sequelae. However, there is no highly effective treatment to enhance post-stroke recovery despite extensive efforts in exploring rehabilitative therapies. Neurorehabilitation is recognized as the cornerstone of functional restoration therapy in stroke, where treatments are focused on neuroplastic regulation to reverse neural structural disruption and improve neurofunctional networks. Post-stroke neuroplasticity changes begin within hours of symptom onset and reaches a plateau by 3 to 4 weeks within the global brain in animal studies. It plays a determining role in spontaneous stroke recovery. Microglia are immediately activated following cerebral ischemia, which has been found both proximal to the primary ischemic injury and at the remote brain regions which have functional connections to the primary injury area. Microglia exhibit different activation profiles based on the microenvironment and adaptively switch their phenotypes in a spatiotemporal manner in response to brain injuries. Microglial activation coincides with neuroplasticity after stroke, which provides the fundamental base for the microglia-mediated inflammatory responses involved in the entire neural network rewiring and brain repair. Microglial activation exerts important effects on spontaneous recovery after stroke, including structural and functional reestablishment of neurovascular networks, neurogenesis, axonal remodeling, and blood vessel regeneration. In this review, we focus on the crosstalk between microglial activation and endogenous neuroplasticity, with a special focus on the plastic alterations in the whole brain network and their implications for structural and functional restoration after stroke. We then summarize recent advances in the impacts of microglial phenotype polarization on brain plasticity, trying to discuss the potential efficacy of microglia-based extrinsic restorative interventions in promoting post-stroke recovery. Frontiers Media S.A. 2021-08-05 /pmc/articles/PMC8374071/ /pubmed/34421544 http://dx.doi.org/10.3389/fncel.2021.727899 Text en Copyright © 2021 Yu, Huang, Ran, Li, Ye, Tian, Xi and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Yu, Fang
Huang, Tingting
Ran, Yuanyuan
Li, Da
Ye, Lin
Tian, Guiqin
Xi, Jianing
Liu, Zongjian
New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title_full New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title_fullStr New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title_full_unstemmed New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title_short New Insights Into the Roles of Microglial Regulation in Brain Plasticity-Dependent Stroke Recovery
title_sort new insights into the roles of microglial regulation in brain plasticity-dependent stroke recovery
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374071/
https://www.ncbi.nlm.nih.gov/pubmed/34421544
http://dx.doi.org/10.3389/fncel.2021.727899
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