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Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells

Forkhead box protein 3 (Foxp3(+))-expressing regulatory T (Treg) cells are a unique CD4(+)T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefo...

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Autores principales: Lu, Jingli, Liang, Yan, Meng, Haiyang, Zhang, Ailing, Zhao, Junjie, Zhang, Chengliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374078/
https://www.ncbi.nlm.nih.gov/pubmed/34421930
http://dx.doi.org/10.3389/fimmu.2021.728783
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author Lu, Jingli
Liang, Yan
Meng, Haiyang
Zhang, Ailing
Zhao, Junjie
Zhang, Chengliang
author_facet Lu, Jingli
Liang, Yan
Meng, Haiyang
Zhang, Ailing
Zhao, Junjie
Zhang, Chengliang
author_sort Lu, Jingli
collection PubMed
description Forkhead box protein 3 (Foxp3(+))-expressing regulatory T (Treg) cells are a unique CD4(+)T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals that altering the metabolic pathways and generation of metabolites can regulate the epigenetics of Treg cells. Specifically, some intermediates of cell metabolism can directly act as substrates or cofactors of epigenetic-modifying enzymes. Here, we describe the metabolic and epigenetic features during Treg cell development, and discuss how metabolites can contribute to epigenetic alterations of Treg cells, which affects Treg cell activation, differentiation, and function.
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spelling pubmed-83740782021-08-20 Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells Lu, Jingli Liang, Yan Meng, Haiyang Zhang, Ailing Zhao, Junjie Zhang, Chengliang Front Immunol Immunology Forkhead box protein 3 (Foxp3(+))-expressing regulatory T (Treg) cells are a unique CD4(+)T cell subset that suppresses excessive immune responses. The epigenetic plasticity and metabolic traits of Treg cells are crucial for the acquisition of their phenotypic and functional characteristics. Therefore, alterations to the epigenetics and metabolism affect Treg cell development and function. Recent evidence reveals that altering the metabolic pathways and generation of metabolites can regulate the epigenetics of Treg cells. Specifically, some intermediates of cell metabolism can directly act as substrates or cofactors of epigenetic-modifying enzymes. Here, we describe the metabolic and epigenetic features during Treg cell development, and discuss how metabolites can contribute to epigenetic alterations of Treg cells, which affects Treg cell activation, differentiation, and function. Frontiers Media S.A. 2021-08-05 /pmc/articles/PMC8374078/ /pubmed/34421930 http://dx.doi.org/10.3389/fimmu.2021.728783 Text en Copyright © 2021 Lu, Liang, Meng, Zhang, Zhao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lu, Jingli
Liang, Yan
Meng, Haiyang
Zhang, Ailing
Zhao, Junjie
Zhang, Chengliang
Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title_full Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title_fullStr Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title_full_unstemmed Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title_short Metabolic Controls on Epigenetic Reprogramming in Regulatory T Cells
title_sort metabolic controls on epigenetic reprogramming in regulatory t cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374078/
https://www.ncbi.nlm.nih.gov/pubmed/34421930
http://dx.doi.org/10.3389/fimmu.2021.728783
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