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Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor
Metal-organic frameworks (MOFs), particularly Zirconium based, have a wide variety of potential applications, such as catalysis and separation. However, these are held back by traditionally only being synthesised in long batch reactions, which causes the process to be expensive and limit the amount...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374184/ https://www.ncbi.nlm.nih.gov/pubmed/34434769 http://dx.doi.org/10.1016/j.mex.2021.101246 |
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author | Bailey, Tom Pinto, Merwyn Hondow, Nicole Wu, Ke-Jun |
author_facet | Bailey, Tom Pinto, Merwyn Hondow, Nicole Wu, Ke-Jun |
author_sort | Bailey, Tom |
collection | PubMed |
description | Metal-organic frameworks (MOFs), particularly Zirconium based, have a wide variety of potential applications, such as catalysis and separation. However, these are held back by traditionally only being synthesised in long batch reactions, which causes the process to be expensive and limit the amount of reaction control available, leading to potential batch to batch variation in the products, such as particle size distributions. Microfluidics allows for batch reactions to be performed with enhanced mass/heat transfer, with the coiled flow inverter reactor (CFIR) setup narrowing the residence time distribution, which is key in controlling the particle size and crystallinity. In this work, a Zirconium based MOF, UiO-67, has been synthesised continuously using a microfluidic CFIR, which has allowed for the product to be formed in 30 min, a fraction of the traditional batch heating time of 24 h. The microfluidicially synthesised UiO-67 is also smaller product with a narrower particle size distribution (≈200 nm to ≈400 nm) than its batch counterpart (~500 nm to over 3 µm). |
format | Online Article Text |
id | pubmed-8374184 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83741842021-08-24 Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor Bailey, Tom Pinto, Merwyn Hondow, Nicole Wu, Ke-Jun MethodsX Method Article Metal-organic frameworks (MOFs), particularly Zirconium based, have a wide variety of potential applications, such as catalysis and separation. However, these are held back by traditionally only being synthesised in long batch reactions, which causes the process to be expensive and limit the amount of reaction control available, leading to potential batch to batch variation in the products, such as particle size distributions. Microfluidics allows for batch reactions to be performed with enhanced mass/heat transfer, with the coiled flow inverter reactor (CFIR) setup narrowing the residence time distribution, which is key in controlling the particle size and crystallinity. In this work, a Zirconium based MOF, UiO-67, has been synthesised continuously using a microfluidic CFIR, which has allowed for the product to be formed in 30 min, a fraction of the traditional batch heating time of 24 h. The microfluidicially synthesised UiO-67 is also smaller product with a narrower particle size distribution (≈200 nm to ≈400 nm) than its batch counterpart (~500 nm to over 3 µm). Elsevier 2021-01-23 /pmc/articles/PMC8374184/ /pubmed/34434769 http://dx.doi.org/10.1016/j.mex.2021.101246 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Method Article Bailey, Tom Pinto, Merwyn Hondow, Nicole Wu, Ke-Jun Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title | Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title_full | Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title_fullStr | Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title_full_unstemmed | Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title_short | Continuous microfluidic synthesis of zirconium-based UiO-67 using a coiled flow invertor reactor |
title_sort | continuous microfluidic synthesis of zirconium-based uio-67 using a coiled flow invertor reactor |
topic | Method Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374184/ https://www.ncbi.nlm.nih.gov/pubmed/34434769 http://dx.doi.org/10.1016/j.mex.2021.101246 |
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