Cargando…

Disorders Related to PI3Kδ Hyperactivation: Characterizing the Clinical and Immunological Features of Activated PI3-Kinase Delta Syndromes

Phosphoinositide-3-kinase δ (PI3Kδ) is found in immune cells and is part of the PI3K/AKT/mTOR/S6K signalling pathway essential to cell survival, growth and differentiation. Hyperactivation of PI3Kδ enzyme results in Activated PI3-kinase delta syndrome (APDS). This childhood onset, autosomal dominant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Redenbaugh, Vyanka, Coulter, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pediatrics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374435/ https://www.ncbi.nlm.nih.gov/pubmed/34422726 http://dx.doi.org/10.3389/fped.2021.702872

Ejemplares similares

The Treatment of Activated PI3Kδ Syndrome
por: Coulter, Tanya I., et al.
Publicado: (2018)

Activated PI3Kinase Delta Syndrome—A Multifaceted Disease
por: Thouenon, Romane, et al.
Publicado: (2021)

ANCA vasculitis expands the spectrum of autoimmune manifestations of activated PI3 kinase δ syndrome
por: Sood, Amika K., et al.
Publicado: (2023)

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity
por: Preite, Silvia, et al.
Publicado: (2018)

A randomized, placebo-controlled phase 3 trial of the PI3Kδ inhibitor leniolisib for activated PI3Kδ syndrome
por: Rao, V. Koneti, et al.
Publicado: (2023)

Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor
por: Cai, Yu, et al.
Publicado: (2020)

Two Monogenetic Disorders, Activated PI3-Kinase-δ Syndrome 2 and Smith–Magenis Syndrome, in One Patient: Case Report and a Literature Review of Neurodevelopmental Impact in Primary Immunodeficiencies Associated With Disturbed PI3K Signaling
por: Moreno-Corona, Nidia, et al.
Publicado: (2021)

Immunodeficiency-Associated Lymphoid Hyperplasia As a Cause of Intussusception in a Case of Activated PI3K-δ Syndrome
por: Mettman, Daniel, et al.
Publicado: (2017)

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ
por: Uehara, Mayuko, et al.
Publicado: (2017)

Case Report: Intestinal Nodular Lymphoid Hyperplasia as First Manifestation of Activated PI3Kδ Syndrome Due to a Novel PIK3CD Variant
por: Marzollo, Antonio, et al.
Publicado: (2021)

The PI3K/Akt signal hyperactivates Eya1 via the SUMOylation pathway
por: Sun, Ye, et al.
Publicado: (2014)

A Review of Phosphocreatine 3 Kinase δ Subtype (PI3Kδ) and Its Inhibitors in Malignancy
por: Xiang, Qiong, et al.
Publicado: (2021)

Roles of PI3Kγ and PI3Kδ in mantle cell lymphoma proliferation and migration contributing to efficacy of the PI3Kγ/δ inhibitor duvelisib
por: Till, Kathleen J., et al.
Publicado: (2023)

Characterization of selective and potent PI3Kδ inhibitor (PI3KD-IN-015) for B-Cell malignances
por: Liu, Xiaochuan, et al.
Publicado: (2016)

Alphavirus-induced hyperactivation of PI3K/AKT directs pro-viral metabolic changes
por: Mazzon, Michela, et al.
Publicado: (2018)

Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
por: Ecker, Veronika, et al.
Publicado: (2021)

Hyper-activated PI3K-δ in immunodeficiency
por: Heurtier, Lucie, et al.
Publicado: (2015)

Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma
por: Katsuya, Hiroo, et al.
Publicado: (2018)

Activated PI3Kδ syndrome 1 mimicking systemic lupus erythematosus and secondary Sjögren's syndrome-like phenotype without recurrent infections: A case report
por: Yin, Jing, et al.
Publicado: (2022)

Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells
por: Compagno, Mara, et al.
Publicado: (2017)

Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors
por: Xin, Minhang, et al.
Publicado: (2018)

Measurement of $\Delta m_s$ in the decay $B^0_s \rightarrow D^-_s(K^+K^-\pi^-)(3)\pi$
por: The LHCb Collaboration
Publicado: (2011)

PI3Kδ is indispensable for CTL-mediated cytotoxicity
por: Putz, Eva M, et al.
Publicado: (2011)

Phenotypic characterization of patients with activated PI3Kδ syndrome 1 presenting with features of systemic lupus erythematosus
por: Wang, Yanping, et al.
Publicado: (2020)

Regulation of p110δ PI 3-Kinase Gene Expression
por: Kok, Klaartje, et al.
Publicado: (2009)

PI3Kδ过度活化综合征一例
Publicado: (2021)

Phosphatidylinositide 3-kinase (PI3K) and PI3K-related kinase (PIKK) activity contributes to radioresistance in thyroid carcinomas
por: Burrows, Natalie, et al.
Publicado: (2016)

Activated PI3 Kinase Delta Syndrome: From Genetics to Therapy
por: Michalovich, David, et al.
Publicado: (2018)

An updated review on activated PI3 kinase delta syndrome (APDS)
por: Singh, Ankita, et al.
Publicado: (2019)

SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta
por: Kirchenwitz, Marco, et al.
Publicado: (2022)

p110δ PI3 kinase pathway: emerging roles in cancer
por: Tzenaki, Niki, et al.
Publicado: (2013)

Natural Course of Activated Phosphoinositide 3-Kinase Delta Syndrome in Childhood and Adolescence
por: Bloomfield, Marketa, et al.
Publicado: (2021)

Measurement of $\Delta m_d$ in $B^0 \rightarrow D^-(K^+\pi^-\pi^-)\pi^+$
por: The LHCb Collaboration
Publicado: (2011)

Understanding the etiology and epidemiology of meningitis and encephalitis: now and into the future
por: Redenbaugh, Vyanka, et al.
Publicado: (2022)

Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure
por: Jia, Wenqing, et al.
Publicado: (2022)

PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes
por: Putz, Eva Maria, et al.
Publicado: (2012)

PI3Kδ Inhibitors as Immunomodulatory Agents for the Treatment of Lymphoma Patients
por: Tarantelli, Chiara, et al.
Publicado: (2021)

Activated PI3Kδ syndrome – reviewing challenges in diagnosis and treatment
por: Vanselow, Sven, et al.
Publicado: (2023)

PI3Kδ inhibition causes feedback activation of PI3Kα in the ABC subtype of diffuse large B-cell lymphoma
por: Pongas, Georgios N., et al.
Publicado: (2017)

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment
por: Piddock, R E, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r5gpn7cjg7lmf8guh0o4v7pfa0