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Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study
INTRODUCTION: It is widely accepted that pathophysiological changes to the central nervous system of persons with Parkinson’s disease (PD) result in negative effects on motor function. However, less information is known regarding the pathology of PD on skeletal muscle. The purpose of this study was...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374465/ https://www.ncbi.nlm.nih.gov/pubmed/34430844 http://dx.doi.org/10.1016/j.prdoa.2021.100103 |
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author | Hammond, Kelley G. Magrini, Mitchel A. Siedlik, Jacob A. Bickel, C. Scott Bamman, Marcas M. |
author_facet | Hammond, Kelley G. Magrini, Mitchel A. Siedlik, Jacob A. Bickel, C. Scott Bamman, Marcas M. |
author_sort | Hammond, Kelley G. |
collection | PubMed |
description | INTRODUCTION: It is widely accepted that pathophysiological changes to the central nervous system of persons with Parkinson’s disease (PD) result in negative effects on motor function. However, less information is known regarding the pathology of PD on skeletal muscle. The purpose of this study was to determine the effect of a fatiguing isometric knee extension protocol on muscle mechanics using evoked twitch contractions in persons with PD and in non-impaired older adults (OLD). METHODS: Evoked twitch contractions were examined during a fatiguing protocol in PD (66 ± 9 yr, n = 8) and OLD (65 ± 10 yr, n = 5). Participants performed 5-sec maximal isometric voluntary contractions of the quadriceps femoris with 5-sec rest for 3-min. Every 30-sec during rest intervals, a maximal transcutaneous electrical stimulus was administered to the quadriceps femoris to quantify evoked peak twitch torque (pTT), peak relaxation rate (pRR), and peak rate of torque development (pRTD). RESULTS: A large effect of voluntary fatigue (%decline) was observed (g = 1.58). There were no significant differences in pTT (p = 0.09; 95% CI:-3.6, 0.28) or pRR (p = 0.11; 95% CI:-31, 3.6). However, the slope decline of pRTD in OLD (-35.4 ± 24.7) was greater than PD (-11.5 ± 11.4; p = 0.03), indicating that skeletal muscle in persons with PD is less fatigable compared to non-impaired older adults. CONCLUSION: The rate, not the maximum capacity, of torque generation of the muscle during a fatiguing knee extension protocol was affected by PD. Future studies are warranted to identify the mechanism(s) responsible for the observed differences in skeletal muscle contractile characteristics and potential myofiber distribution variation in PD. |
format | Online Article Text |
id | pubmed-8374465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-83744652021-08-23 Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study Hammond, Kelley G. Magrini, Mitchel A. Siedlik, Jacob A. Bickel, C. Scott Bamman, Marcas M. Clin Park Relat Disord Original Article INTRODUCTION: It is widely accepted that pathophysiological changes to the central nervous system of persons with Parkinson’s disease (PD) result in negative effects on motor function. However, less information is known regarding the pathology of PD on skeletal muscle. The purpose of this study was to determine the effect of a fatiguing isometric knee extension protocol on muscle mechanics using evoked twitch contractions in persons with PD and in non-impaired older adults (OLD). METHODS: Evoked twitch contractions were examined during a fatiguing protocol in PD (66 ± 9 yr, n = 8) and OLD (65 ± 10 yr, n = 5). Participants performed 5-sec maximal isometric voluntary contractions of the quadriceps femoris with 5-sec rest for 3-min. Every 30-sec during rest intervals, a maximal transcutaneous electrical stimulus was administered to the quadriceps femoris to quantify evoked peak twitch torque (pTT), peak relaxation rate (pRR), and peak rate of torque development (pRTD). RESULTS: A large effect of voluntary fatigue (%decline) was observed (g = 1.58). There were no significant differences in pTT (p = 0.09; 95% CI:-3.6, 0.28) or pRR (p = 0.11; 95% CI:-31, 3.6). However, the slope decline of pRTD in OLD (-35.4 ± 24.7) was greater than PD (-11.5 ± 11.4; p = 0.03), indicating that skeletal muscle in persons with PD is less fatigable compared to non-impaired older adults. CONCLUSION: The rate, not the maximum capacity, of torque generation of the muscle during a fatiguing knee extension protocol was affected by PD. Future studies are warranted to identify the mechanism(s) responsible for the observed differences in skeletal muscle contractile characteristics and potential myofiber distribution variation in PD. Elsevier 2021-08-08 /pmc/articles/PMC8374465/ /pubmed/34430844 http://dx.doi.org/10.1016/j.prdoa.2021.100103 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Article Hammond, Kelley G. Magrini, Mitchel A. Siedlik, Jacob A. Bickel, C. Scott Bamman, Marcas M. Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title | Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title_full | Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title_fullStr | Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title_full_unstemmed | Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title_short | Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: A pilot study |
title_sort | influence of muscle fatigue on contractile twitch characteristics in persons with parkinson’s disease and older adults: a pilot study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374465/ https://www.ncbi.nlm.nih.gov/pubmed/34430844 http://dx.doi.org/10.1016/j.prdoa.2021.100103 |
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