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The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum

BACKGROUND: Several SARS-CoV-2 lineages with spike receptor binding domain (RBD) N501Y mutation have spread globally. We evaluated the impact of N501Y on neutralizing activity of COVID-19 convalescent sera and on anti-RBD IgG assays. METHODS: The susceptibility to neutralization by COVID-19 patients...

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Detalles Bibliográficos
Autores principales:	Lu, Lu, Chu, Allen Wing-Ho, Zhang, Ricky Ruiqi, Chan, Wan-Mui, Ip, Jonathan Daniel, Tsoi, Hoi-Wah, Chen, Lin-lei, Cai, Jian-Piao, Lung, David Christopher, Tam, Anthony Raymond, Yau, Yat-Sun, Kwan, Mike Yat-Wah, To, Wing-Kin, Tsang, Owen Tak-Yin, Lee, Larry Lap-Yip, Yi, Haisu, Ip, Tak-Chuen, Poon, Rosana Wing-Shan, Siu, Gilman Kit-Hang, Mok, Bobo Wing-Yee, Cheng, Vincent Chi-Chung, Chan, Kwok Hung, Yuen, Kwok-Yung, Hung, Ivan Fan-Ngai, To, Kelvin Kai-Wang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374549/ https://www.ncbi.nlm.nih.gov/pubmed/34419925 http://dx.doi.org/10.1016/j.ebiom.2021.103544

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