Cargando…

(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls: a cross-sectional study

(11)C-PK11195 is a positron emitter tracer used for Positron Emission Tomography (PET) imaging of innate immune cell activation in studies of neuroinflammatory diseases. For the image quantitative analysis, it is necessary to quantify the intact fraction of this tracer in the arterial plasma during...

Descripción completa

Detalles Bibliográficos
Autores principales:	de Souza, Aline Morais, Pitombeira, Milena Sales, de Souza, Larissa Estessi, Marques, Fabio Luiz Navarro, Buchpiguel, Carlos Alberto, Real, Caroline Cristiano, de Paula Faria, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer - Medknow 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374550/ https://www.ncbi.nlm.nih.gov/pubmed/33907039 http://dx.doi.org/10.4103/1673-5374.313062

Ejemplares similares

Potential of [(11)C](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
por: de Souza, Aline Morais, et al.
Publicado: (2022)

Cannabidiol Treatment Improves Glucose Metabolism and Memory in Streptozotocin-Induced Alzheimer’s Disease Rat Model: A Proof-of-Concept Study
por: de Paula Faria, Daniele, et al.
Publicado: (2022)

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195
por: Guedes, Carlos Eduardo Sampaio, et al.
Publicado: (2018)

[(11)C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy
por: Passamonti, Luca, et al.
Publicado: (2018)

Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.
por: da Silva, Marcelo Barreto Spillere, et al.
Publicado: (2004)

Abnormal neuroinflammation in fibromyalgia and CRPS using [(11)C]-(R)-PK11195 PET
por: Seo, Seongho, et al.
Publicado: (2021)

The protective effect of PK11195 on D-galactose-induced amnestic mild cognitive impairment in rats
por: Ye, Chen, et al.
Publicado: (2020)

(11)C‐PK11195 PET imaging and white matter changes in Parkinson’s disease dementia
por: Nicastro, Nicolas, et al.
Publicado: (2019)

[(11)C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease
por: van den Ameele, Jelle, et al.
Publicado: (2021)

Textural properties of microglial activation in Alzheimer’s disease as measured by (R)-[(11)C]PK11195 PET
por: Lapo Pais, Marta, et al.
Publicado: (2023)

In vivo (R)-[(11)C]PK11195 PET imaging of 18kDa translocator protein in recent onset psychosis
por: van der Doef, Thalia F, et al.
Publicado: (2016)

The TSPO-specific Ligand PK11195 Protects Against LPS-Induced Cognitive Dysfunction by Inhibiting Cellular Autophagy
por: Lan, Nannan, et al.
Publicado: (2021)

[(18)F]DPA-714: Direct Comparison with [(11)C]PK11195 in a Model of Cerebral Ischemia in Rats
por: Boutin, Hervé, et al.
Publicado: (2013)

[(11)C]-(R)PK11195 tracer kinetics in the brain of glioma patients and a comparison of two referencing approaches
por: Su, Zhangjie, et al.
Publicado: (2013)

Noninvasive PK11195‐PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease
por: Kang, Yeona, et al.
Publicado: (2018)

(11)C‐PK11195 PET–based molecular study of microglia activation in SOD1 amyotrophic lateral sclerosis
por: Tondo, Giacomo, et al.
Publicado: (2020)

PK11195 Protects From Cell Death Only When Applied During Reperfusion: Succinate-Mediated Mechanism of Action
por: Seidlmayer, Lea K., et al.
Publicado: (2021)

Evaluation of age-related changes in translocator protein (TSPO) in human brain using (11)C-[R]-PK11195 PET
por: Kumar, Ajay, et al.
Publicado: (2012)

[(11)C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: A pilot study
por: Jeon, So Yeon, et al.
Publicado: (2017)

Test-retest reliability and convergent validity of (R)-[(11)C]PK11195 outcome measures without arterial input function
por: Plavén-Sigray, Pontus, et al.
Publicado: (2018)

TSPO Ligands PK11195 and Midazolam Reduce NLRP3 Inflammasome Activation and Proinflammatory Cytokine Release in BV-2 Cells
por: Feng, Hao, et al.
Publicado: (2020)

Have (R)-[(11)C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies
por: Chauveau, Fabien, et al.
Publicado: (2021)

Bcl-2 resistant mitochondrial toxicity mediated by the isoquinoline carboxamide PK11195 involves de novo generation of reactive oxygen species
por: Fennell, D A, et al.
Publicado: (2001)

Optimization of supervised cluster analysis for extracting reference tissue input curves in (R)-[(11)C]PK11195 brain PET studies
por: Yaqub, Maqsood, et al.
Publicado: (2012)

No Signs of Neuroinflammation in Women With Chronic Fatigue Syndrome or Q Fever Fatigue Syndrome Using the TSPO Ligand [(11)C]-PK11195
por: Raijmakers, Ruud, et al.
Publicado: (2021)

The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines
por: Amara, Rula, et al.
Publicado: (2022)

Evaluation of (R)-[(11)C]PK11195 PET/MRI for Spinal Cord-Related Neuropathic Pain in Patients with Cervical Spinal Disorders
por: Kitade, Makoto, et al.
Publicado: (2022)

PT637. [11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: a pilot study
por: Jeon, Soyeon
Publicado: (2016)

Analysis of PK11195 concentrations in rodent whole blood and tissue samples by rapid and reproducible chromatographic method to support target-occupancy PET studies
por: Stadulytė, Agnė, et al.
Publicado: (2019)

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue
por: Ni, Ruiqing, et al.
Publicado: (2021)

The TSPO Ligands 2-Cl-MGV-1, MGV-1, and PK11195 Differentially Suppress the Inflammatory Response of BV-2 Microglial Cell to LPS
por: Azrad, Maya, et al.
Publicado: (2019)

The Effects of PK11195 and Protoporphyrin IX Can Modulate Chronic Alcohol Intoxication in Rat Liver Mitochondria under the Opening of the Mitochondrial Permeability Transition Pore
por: Baburina, Yulia, et al.
Publicado: (2020)

Increased cerebral (R)-[(11)C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study
por: Folkersma, Hedy, et al.
Publicado: (2011)

Kinetic analysis and test-retest variability of the radioligand [(11)C](R)-PK11195 binding to TSPO in the human brain - a PET study in control subjects
por: Jučaite, Aurelija, et al.
Publicado: (2012)

Comparison of two different methods of image analysis for the assessment of microglial activation in patients with multiple sclerosis using (R)-[N-methyl-carbon-11]PK11195
por: Kang, Yeona, et al.
Publicado: (2018)

Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [(11)C]-(R)-PK11195 PET and MRI
por: Yankam Njiwa, J, et al.
Publicado: (2016)

[(11)C]-DPA-713 and [(18)F]-DPA-714 as New PET Tracers for TSPO: A Comparison with [(11)C]-(R)-PK11195 in a Rat Model of Herpes Encephalitis
por: Doorduin, Janine, et al.
Publicado: (2009)

Carotid artery plaque uptake of (11)C-PK11195 inversely correlates with circulating monocytes and classical CD14(++)CD16(−) monocytes expressing HLA-DR
por: Ammirati, Enrico, et al.
Publicado: (2018)

A Modest Increase in (11)C-PK11195-Positron Emission Tomography TSPO Binding in Depression Is Not Associated With Serum C-Reactive Protein or Body Mass Index
por: Schubert, Julia J., et al.
Publicado: (2021)

In Vivo Cerebral Translocator Protein (TSPO) Binding and Its Relationship with Blood Adiponectin Levels in Treatment-Naïve Young Adults with Major Depression: A [(11)C]PK11195 PET Study
por: Joo, Yo-Han, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5679pgmo61ch8j11c7b3tlbg97