Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis

The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown and surgical resection has not been optimized. A 39‐year‐old woman was administrated methylprednisolone for newly diagnosed multiple sclerosis. A thymic tumour was found in the antero‐superior mediastinum via...

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Detalles Bibliográficos
Autores principales: Isono, Tomomi, Ose, Naoko, Kawasaki, Keisuke, Shibata, Ayumi, Funaki, Soichiro, Shintani, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374605/
https://www.ncbi.nlm.nih.gov/pubmed/34457311
http://dx.doi.org/10.1002/rcr2.834
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author Isono, Tomomi
Ose, Naoko
Kawasaki, Keisuke
Shibata, Ayumi
Funaki, Soichiro
Shintani, Yasushi
author_facet Isono, Tomomi
Ose, Naoko
Kawasaki, Keisuke
Shibata, Ayumi
Funaki, Soichiro
Shintani, Yasushi
author_sort Isono, Tomomi
collection PubMed
description The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown and surgical resection has not been optimized. A 39‐year‐old woman was administrated methylprednisolone for newly diagnosed multiple sclerosis. A thymic tumour was found in the antero‐superior mediastinum via computed tomography of the chest. Video‐assisted thoracoscopic thymectomy was performed. Histologically, the tumour was diagnosed as Type AB thymoma. Immunohistochemical staining showed positive myelin basic protein (MBP) in the cytosol of spindle cells in the tumour specimen. Germinal centres or lymphocytes infiltration were not noted. Ectopic MBP presentation in thymoma might be correlated with DD.
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spelling pubmed-83746052021-08-26 Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis Isono, Tomomi Ose, Naoko Kawasaki, Keisuke Shibata, Ayumi Funaki, Soichiro Shintani, Yasushi Respirol Case Rep Case Reports The relationship between thymic epithelial tumour and demyelinating disease (DD) is unknown and surgical resection has not been optimized. A 39‐year‐old woman was administrated methylprednisolone for newly diagnosed multiple sclerosis. A thymic tumour was found in the antero‐superior mediastinum via computed tomography of the chest. Video‐assisted thoracoscopic thymectomy was performed. Histologically, the tumour was diagnosed as Type AB thymoma. Immunohistochemical staining showed positive myelin basic protein (MBP) in the cytosol of spindle cells in the tumour specimen. Germinal centres or lymphocytes infiltration were not noted. Ectopic MBP presentation in thymoma might be correlated with DD. John Wiley & Sons, Ltd 2021-08-19 /pmc/articles/PMC8374605/ /pubmed/34457311 http://dx.doi.org/10.1002/rcr2.834 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Case Reports
Isono, Tomomi
Ose, Naoko
Kawasaki, Keisuke
Shibata, Ayumi
Funaki, Soichiro
Shintani, Yasushi
Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title_full Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title_fullStr Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title_full_unstemmed Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title_short Myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
title_sort myelin basic protein expression in thymoma after methylprednisolone administration for multiple sclerosis
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374605/
https://www.ncbi.nlm.nih.gov/pubmed/34457311
http://dx.doi.org/10.1002/rcr2.834
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