Metformin inhibits MAPK signaling and rescues pancreatic aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus

Metformin is the first-line antidiabetic agent for type 2 diabetes mellitus (T2DM) treatment. Although accumulated evidence has shed light on the consequences of metformin action, the precise mechanisms of its action, especially in the pancreas, are not fully understood. Aquaporin 7 (AQP7) acts as a...

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Detalles Bibliográficos
Autores principales: He, Xueting, Gao, Fei, Hou, Jiaojiao, Li, Tingjie, Tan, Jiang, Wang, Chunyu, Liu, Xiaoyan, Wang, Maoqi, Liu, Hui, Chen, Yuqin, Yu, Zhuoyuan, Yang, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374641/
https://www.ncbi.nlm.nih.gov/pubmed/34303707
http://dx.doi.org/10.1016/j.jbc.2021.101002

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