A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A–dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia

Glycinergic neurons and glycine receptors (GlyRs) exert a critical control over spinal nociception. Prostaglandin E(2) (PGE(2)), a key inflammatory mediator produced in the spinal cord in response to peripheral inflammation, inhibits a certain subtype of GlyRs (α3GlyR) that is defined by the inclusi...

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Detalles Bibliográficos
Autores principales: Werynska, Karolina, Gingras, Jacinthe, Benke, Dietmar, Scheurer, Louis, Neumann, Elena, Zeilhofer, Hanns Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374710/
https://www.ncbi.nlm.nih.gov/pubmed/34264571
http://dx.doi.org/10.1097/j.pain.0000000000002236

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