Cargando…

Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia

PURPOSE: It is well known that age is related to the incidence of Mycoplasma pneumoniae pneumonia (MPP), and how age and other factors contribute to MPP remains unclear. In this study, we investigate how age affects the prognosis of MPP. PATIENTS AND METHODS: A total number of 1875 hospitalized chil...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Qianye, Zhang, Teng, Zhu, Beibei, Bi, Ying, Jiang, Shi-Wen, Zhu, Yifan, Zhao, Deyu, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374848/
https://www.ncbi.nlm.nih.gov/pubmed/34429628
http://dx.doi.org/10.2147/JIR.S321656
_version_ 1783740203687477248
author Zhao, Qianye
Zhang, Teng
Zhu, Beibei
Bi, Ying
Jiang, Shi-Wen
Zhu, Yifan
Zhao, Deyu
Liu, Feng
author_facet Zhao, Qianye
Zhang, Teng
Zhu, Beibei
Bi, Ying
Jiang, Shi-Wen
Zhu, Yifan
Zhao, Deyu
Liu, Feng
author_sort Zhao, Qianye
collection PubMed
description PURPOSE: It is well known that age is related to the incidence of Mycoplasma pneumoniae pneumonia (MPP), and how age and other factors contribute to MPP remains unclear. In this study, we investigate how age affects the prognosis of MPP. PATIENTS AND METHODS: A total number of 1875 hospitalized children with pneumonia were enrolled in this study, including 52 children with refractory M. pneumoniae pneumonia (RMPP) and 298 children with non-RMPP. We used multiple logistic regression analysis to further identify the risk factors of RMPP, and found that age and polymorphonuclear neutrophils (PMNs) count were the key independent risk factors for the occurrence of RMPP. In order to improve specificity, 4.5 years old was taken as the cut-off value. Then, according to the cut-off value of age, 76 participants were recruited and divided into four groups: <4.5y MPP group, ≥4.5y MPP group, <4.5y health control (<4.5yHC) and ≥4.5y HC group. We explored the diverse functions of primary PMNs from children of different ages with MPP at cellular level. Besides, we studied the relationship between lung injury and PMNs in mice model with MPP of different ages. RESULTS: We found that the age and PMNs count of RMPP group were significantly higher than those of the non-RMPP group. Importantly, there is a linear correlation between the age of patients with RMPP and the percentage of PMNs. Further analysis showed that elderly patients infected with M. pneumoniae had more active PMNs function. Meanwhile, proteomics showed that children with M. pneumoniae infection in different age groups have differences in PMNs apoptosis, nicotinamide adenine dinucleotide phosphate, mitochondrial function and oxidative stress. Finally, we found that age is also involved in the pathogenesis of mouse model with MPP. CONCLUSION: We speculate that age may contribute to the development of RMPP.
format Online
Article
Text
id pubmed-8374848
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-83748482021-08-23 Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia Zhao, Qianye Zhang, Teng Zhu, Beibei Bi, Ying Jiang, Shi-Wen Zhu, Yifan Zhao, Deyu Liu, Feng J Inflamm Res Original Research PURPOSE: It is well known that age is related to the incidence of Mycoplasma pneumoniae pneumonia (MPP), and how age and other factors contribute to MPP remains unclear. In this study, we investigate how age affects the prognosis of MPP. PATIENTS AND METHODS: A total number of 1875 hospitalized children with pneumonia were enrolled in this study, including 52 children with refractory M. pneumoniae pneumonia (RMPP) and 298 children with non-RMPP. We used multiple logistic regression analysis to further identify the risk factors of RMPP, and found that age and polymorphonuclear neutrophils (PMNs) count were the key independent risk factors for the occurrence of RMPP. In order to improve specificity, 4.5 years old was taken as the cut-off value. Then, according to the cut-off value of age, 76 participants were recruited and divided into four groups: <4.5y MPP group, ≥4.5y MPP group, <4.5y health control (<4.5yHC) and ≥4.5y HC group. We explored the diverse functions of primary PMNs from children of different ages with MPP at cellular level. Besides, we studied the relationship between lung injury and PMNs in mice model with MPP of different ages. RESULTS: We found that the age and PMNs count of RMPP group were significantly higher than those of the non-RMPP group. Importantly, there is a linear correlation between the age of patients with RMPP and the percentage of PMNs. Further analysis showed that elderly patients infected with M. pneumoniae had more active PMNs function. Meanwhile, proteomics showed that children with M. pneumoniae infection in different age groups have differences in PMNs apoptosis, nicotinamide adenine dinucleotide phosphate, mitochondrial function and oxidative stress. Finally, we found that age is also involved in the pathogenesis of mouse model with MPP. CONCLUSION: We speculate that age may contribute to the development of RMPP. Dove 2021-08-14 /pmc/articles/PMC8374848/ /pubmed/34429628 http://dx.doi.org/10.2147/JIR.S321656 Text en © 2021 Zhao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhao, Qianye
Zhang, Teng
Zhu, Beibei
Bi, Ying
Jiang, Shi-Wen
Zhu, Yifan
Zhao, Deyu
Liu, Feng
Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title_full Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title_fullStr Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title_full_unstemmed Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title_short Increasing Age Affected Polymorphonuclear Neutrophils in Prognosis of Mycoplasma pneumoniae Pneumonia
title_sort increasing age affected polymorphonuclear neutrophils in prognosis of mycoplasma pneumoniae pneumonia
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374848/
https://www.ncbi.nlm.nih.gov/pubmed/34429628
http://dx.doi.org/10.2147/JIR.S321656
work_keys_str_mv AT zhaoqianye increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT zhangteng increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT zhubeibei increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT biying increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT jiangshiwen increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT zhuyifan increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT zhaodeyu increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia
AT liufeng increasingageaffectedpolymorphonuclearneutrophilsinprognosisofmycoplasmapneumoniaepneumonia