The RAG1 N-terminal region regulates the efficiency and pathways of synapsis for V(D)J recombination

Immunoglobulin and T cell receptor gene assembly depends on V(D)J recombination initiated by the RAG1-RAG2 recombinase. The RAG1 N-terminal region (NTR; aa 1–383) has been implicated in regulatory functions whose influence on V(D)J recombination and lymphocyte development in vivo is poorly understoo...

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Detalles Bibliográficos
Autores principales: Beilinson, Helen A., Glynn, Rebecca A., Yadavalli, Anurupa Devi, Xiao, Jianxiong, Corbett, Elizabeth, Saribasak, Huseyin, Arya, Rahul, Miot, Charline, Bhattacharyya, Anamika, Jones, Jessica M., Pongubala, Jagan M.R., Bassing, Craig H., Schatz, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374863/
https://www.ncbi.nlm.nih.gov/pubmed/34402853
http://dx.doi.org/10.1084/jem.20210250

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