Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here, we describe three pro-regenerative factors; fibroblast growth f...

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Detalles Bibliográficos
Autores principales: Keppie, Stuart J, Mansfield, Jessica C, Tang, Xiaodi, Philp, Christopher J, Graham, Helen K, Önnerfjord, Patrik, Wall, Alanna, McLean, Celia, Winlove, C Peter, Sherratt, Michael J, Pavlovskaya, Galina E, Vincent, Tonia L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374957/
https://www.ncbi.nlm.nih.gov/pubmed/34423304
http://dx.doi.org/10.1093/function/zqab037

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