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Dopaminergic restoration of prefrontal cortico-putaminal network in gene therapy for aromatic l-amino acid decarboxylase deficiency

Aromatic l-amino acid decarboxylase (AADC) is an essential dopamine-synthesizing enzyme. In children with AADC deficiency, the gene delivery of AADC into the putamen, which functionally interacts with cortical regions, was found to improve motor function and ameliorate dystonia. However, how the res...

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Detalles Bibliográficos
Autores principales:	Onuki, Yoshiyuki, Ono, Sayaka, Nakajima, Takeshi, Kojima, Karin, Taga, Naoyuki, Ikeda, Takahiro, Kuwajima, Mari, Kurokawa, Yoshie, Kato, Mitsuhiro, Kawai, Kensuke, Osaka, Hitoshi, Sato, Toshihiko, Muramatsu, Shin-ichi, Yamagata, Takanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8374966/ https://www.ncbi.nlm.nih.gov/pubmed/34423296 http://dx.doi.org/10.1093/braincomms/fcab078

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