Increased Susceptibility and Intrinsic Apoptotic Signaling in Neurons by Induced HDAC3 Expression

PURPOSE: Inhibition or targeted deletion of histone deacetylase 3 (HDAC3) is neuroprotective in a variety neurodegenerative conditions, including retinal ganglion cells (RGCs) after acute optic nerve damage. Consistent with this, induced HDAC3 expression in cultured cells shows selective toxicity to...

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Detalles Bibliográficos
Autores principales: Schmitt, Heather M., Fehrman, Rachel L., Maes, Margaret E., Yang, Huan, Guo, Lian-Wang, Schlamp, Cassandra L., Pelzel, Heather R., Nickells, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375002/
https://www.ncbi.nlm.nih.gov/pubmed/34398198
http://dx.doi.org/10.1167/iovs.62.10.14

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