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The Mechanisms of Sevoflurane-Induced Neuroinflammation

Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation...

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Autores principales: Huang, Xiangfei, Ying, Jun, Yang, Danying, Fang, Pu, Wang, Xifeng, Zhou, Bin, Zhang, Lieliang, Fang, Yang, Yu, Wen, Liu, Xing, Zhen, Qingcui, Hua, Fuzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375153/
https://www.ncbi.nlm.nih.gov/pubmed/34421578
http://dx.doi.org/10.3389/fnagi.2021.717745
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author Huang, Xiangfei
Ying, Jun
Yang, Danying
Fang, Pu
Wang, Xifeng
Zhou, Bin
Zhang, Lieliang
Fang, Yang
Yu, Wen
Liu, Xing
Zhen, Qingcui
Hua, Fuzhou
author_facet Huang, Xiangfei
Ying, Jun
Yang, Danying
Fang, Pu
Wang, Xifeng
Zhou, Bin
Zhang, Lieliang
Fang, Yang
Yu, Wen
Liu, Xing
Zhen, Qingcui
Hua, Fuzhou
author_sort Huang, Xiangfei
collection PubMed
description Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood–brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment.
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spelling pubmed-83751532021-08-20 The Mechanisms of Sevoflurane-Induced Neuroinflammation Huang, Xiangfei Ying, Jun Yang, Danying Fang, Pu Wang, Xifeng Zhou, Bin Zhang, Lieliang Fang, Yang Yu, Wen Liu, Xing Zhen, Qingcui Hua, Fuzhou Front Aging Neurosci Neuroscience Sevoflurane is one of the most commonly used inhaled anesthetics due to its low blood gas coefficient, fast onset, low airway irritation, and aromatic smell. However, recent studies have reported that sevoflurane exposure may have deleterious effects on cognitive function. Although neuroinflammation was most widely mentioned among the established mechanisms of sevoflurane-induced cognitive dysfunction, its upstream mechanisms have yet to be illustrated. Thus, we reviewed the relevant literature and discussed the most mentioned mechanisms, including the modulation of the microglial function, blood–brain barrier (BBB) breakdown, changes in gut microbiota, and ease of cholinergic neurotransmission to help us understand the properties of sevoflurane, providing us new perspectives for the prevention of sevoflurane-induced cognitive impairment. Frontiers Media S.A. 2021-08-05 /pmc/articles/PMC8375153/ /pubmed/34421578 http://dx.doi.org/10.3389/fnagi.2021.717745 Text en Copyright © 2021 Huang, Ying, Yang, Fang, Wang, Zhou, Zhang, Fang, Yu, Liu, Zhen and Hua. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Huang, Xiangfei
Ying, Jun
Yang, Danying
Fang, Pu
Wang, Xifeng
Zhou, Bin
Zhang, Lieliang
Fang, Yang
Yu, Wen
Liu, Xing
Zhen, Qingcui
Hua, Fuzhou
The Mechanisms of Sevoflurane-Induced Neuroinflammation
title The Mechanisms of Sevoflurane-Induced Neuroinflammation
title_full The Mechanisms of Sevoflurane-Induced Neuroinflammation
title_fullStr The Mechanisms of Sevoflurane-Induced Neuroinflammation
title_full_unstemmed The Mechanisms of Sevoflurane-Induced Neuroinflammation
title_short The Mechanisms of Sevoflurane-Induced Neuroinflammation
title_sort mechanisms of sevoflurane-induced neuroinflammation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375153/
https://www.ncbi.nlm.nih.gov/pubmed/34421578
http://dx.doi.org/10.3389/fnagi.2021.717745
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