Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?

Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recom...

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Autores principales: Ghieh, Farah, Barbotin, Anne-Laure, Leroy, Clara, Marcelli, François, Swierkowsky-Blanchard, Nelly, Serazin, Valérie, Mandon-Pepin, Béatrice, Vialard, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375164/
https://www.ncbi.nlm.nih.gov/pubmed/34407766
http://dx.doi.org/10.1186/s12610-021-00138-4
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author Ghieh, Farah
Barbotin, Anne-Laure
Leroy, Clara
Marcelli, François
Swierkowsky-Blanchard, Nelly
Serazin, Valérie
Mandon-Pepin, Béatrice
Vialard, François
author_facet Ghieh, Farah
Barbotin, Anne-Laure
Leroy, Clara
Marcelli, François
Swierkowsky-Blanchard, Nelly
Serazin, Valérie
Mandon-Pepin, Béatrice
Vialard, François
author_sort Ghieh, Farah
collection PubMed
description Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recommend WES or whole-genome sequencing (WGS) after genetic counselling, an objective evaluation of the current genetic screening strategy for male infertility is required, even if, at present, we have to take into consideration the complexity of such a procedure, not discussed in this commentary.
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spelling pubmed-83751642021-08-19 Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future? Ghieh, Farah Barbotin, Anne-Laure Leroy, Clara Marcelli, François Swierkowsky-Blanchard, Nelly Serazin, Valérie Mandon-Pepin, Béatrice Vialard, François Basic Clin Androl Commentary Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recommend WES or whole-genome sequencing (WGS) after genetic counselling, an objective evaluation of the current genetic screening strategy for male infertility is required, even if, at present, we have to take into consideration the complexity of such a procedure, not discussed in this commentary. BioMed Central 2021-08-19 /pmc/articles/PMC8375164/ /pubmed/34407766 http://dx.doi.org/10.1186/s12610-021-00138-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Ghieh, Farah
Barbotin, Anne-Laure
Leroy, Clara
Marcelli, François
Swierkowsky-Blanchard, Nelly
Serazin, Valérie
Mandon-Pepin, Béatrice
Vialard, François
Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title_full Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title_fullStr Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title_full_unstemmed Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title_short Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
title_sort will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375164/
https://www.ncbi.nlm.nih.gov/pubmed/34407766
http://dx.doi.org/10.1186/s12610-021-00138-4
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