The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation

Background: Chronic diabetes accelerates vascular dysfunction often resulting in cardiomyopathy but underlying mechanisms remain unclear. Recent studies have shown that the deregulated unfolded protein response (UPR) dependent on highly conserved IRE1α-spliced X-box- binding protein (XBP1s) and the...

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Detalles Bibliográficos
Autores principales: Wang, Tao, Wu, Jinhua, Dong, Wei, Wang, Mengwen, Zhong, Xiaodan, Zhang, Wenjun, Dai, Lei, Xie, Yang, Liu, Yujian, He, Xingwei, Liu, Wanjun, Madhusudhan, Thati, Zeng, Hesong, Wang, Hongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375222/
https://www.ncbi.nlm.nih.gov/pubmed/34421344
http://dx.doi.org/10.7150/ijbs.60459

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