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SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway

Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and...

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Autores principales: Zeng, Bin, Sun, Zhiwei, Zhao, Qiting, Liu, Doudou, chen, Hao, Li, Xiaoshuang, Xing, H. Rosie, Wang, Jianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375231/
https://www.ncbi.nlm.nih.gov/pubmed/34421345
http://dx.doi.org/10.7150/ijbs.60866
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author Zeng, Bin
Sun, Zhiwei
Zhao, Qiting
Liu, Doudou
chen, Hao
Li, Xiaoshuang
Xing, H. Rosie
Wang, Jianyu
author_facet Zeng, Bin
Sun, Zhiwei
Zhao, Qiting
Liu, Doudou
chen, Hao
Li, Xiaoshuang
Xing, H. Rosie
Wang, Jianyu
author_sort Zeng, Bin
collection PubMed
description Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and POL (polymetastatic) that differ in their metastatic colonization capability, we have elucidated a new mechanism involving “SEC23A-PF4-MAPK/ERK axis” in which PF4 transported by COPII hinders metastasis through inhibition of MAPK/ERK signaling pathway. Furthermore, SPARC can act cooperatively to enhance the inhibition of Pf4 on ERK phosphorylation and melanoma cell metastasis. Our findings show the possibility of targeting cancer cell secretome for therapeutic development.
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spelling pubmed-83752312021-08-19 SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway Zeng, Bin Sun, Zhiwei Zhao, Qiting Liu, Doudou chen, Hao Li, Xiaoshuang Xing, H. Rosie Wang, Jianyu Int J Biol Sci Research Paper Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and POL (polymetastatic) that differ in their metastatic colonization capability, we have elucidated a new mechanism involving “SEC23A-PF4-MAPK/ERK axis” in which PF4 transported by COPII hinders metastasis through inhibition of MAPK/ERK signaling pathway. Furthermore, SPARC can act cooperatively to enhance the inhibition of Pf4 on ERK phosphorylation and melanoma cell metastasis. Our findings show the possibility of targeting cancer cell secretome for therapeutic development. Ivyspring International Publisher 2021-07-13 /pmc/articles/PMC8375231/ /pubmed/34421345 http://dx.doi.org/10.7150/ijbs.60866 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Zeng, Bin
Sun, Zhiwei
Zhao, Qiting
Liu, Doudou
chen, Hao
Li, Xiaoshuang
Xing, H. Rosie
Wang, Jianyu
SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title_full SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title_fullStr SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title_full_unstemmed SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title_short SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
title_sort sec23a inhibit melanoma metastatic through secretory pf4 cooperation with sparc to inhibit mapk signaling pathway
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375231/
https://www.ncbi.nlm.nih.gov/pubmed/34421345
http://dx.doi.org/10.7150/ijbs.60866
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