Cargando…
SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway
Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375231/ https://www.ncbi.nlm.nih.gov/pubmed/34421345 http://dx.doi.org/10.7150/ijbs.60866 |
_version_ | 1783740281457213440 |
---|---|
author | Zeng, Bin Sun, Zhiwei Zhao, Qiting Liu, Doudou chen, Hao Li, Xiaoshuang Xing, H. Rosie Wang, Jianyu |
author_facet | Zeng, Bin Sun, Zhiwei Zhao, Qiting Liu, Doudou chen, Hao Li, Xiaoshuang Xing, H. Rosie Wang, Jianyu |
author_sort | Zeng, Bin |
collection | PubMed |
description | Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and POL (polymetastatic) that differ in their metastatic colonization capability, we have elucidated a new mechanism involving “SEC23A-PF4-MAPK/ERK axis” in which PF4 transported by COPII hinders metastasis through inhibition of MAPK/ERK signaling pathway. Furthermore, SPARC can act cooperatively to enhance the inhibition of Pf4 on ERK phosphorylation and melanoma cell metastasis. Our findings show the possibility of targeting cancer cell secretome for therapeutic development. |
format | Online Article Text |
id | pubmed-8375231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-83752312021-08-19 SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway Zeng, Bin Sun, Zhiwei Zhao, Qiting Liu, Doudou chen, Hao Li, Xiaoshuang Xing, H. Rosie Wang, Jianyu Int J Biol Sci Research Paper Metastasis of melanoma to the distant organs is a multistep process in which the tumor microenvironment (TME) may play an important role. However, the relationship between metastatic progression and TME is intricate. In the present study, using melanoma derivative cell lines OL (oligometastatic) and POL (polymetastatic) that differ in their metastatic colonization capability, we have elucidated a new mechanism involving “SEC23A-PF4-MAPK/ERK axis” in which PF4 transported by COPII hinders metastasis through inhibition of MAPK/ERK signaling pathway. Furthermore, SPARC can act cooperatively to enhance the inhibition of Pf4 on ERK phosphorylation and melanoma cell metastasis. Our findings show the possibility of targeting cancer cell secretome for therapeutic development. Ivyspring International Publisher 2021-07-13 /pmc/articles/PMC8375231/ /pubmed/34421345 http://dx.doi.org/10.7150/ijbs.60866 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Zeng, Bin Sun, Zhiwei Zhao, Qiting Liu, Doudou chen, Hao Li, Xiaoshuang Xing, H. Rosie Wang, Jianyu SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title_full | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title_fullStr | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title_full_unstemmed | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title_short | SEC23A Inhibit Melanoma Metastatic through Secretory PF4 Cooperation with SPARC to Inhibit MAPK Signaling Pathway |
title_sort | sec23a inhibit melanoma metastatic through secretory pf4 cooperation with sparc to inhibit mapk signaling pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375231/ https://www.ncbi.nlm.nih.gov/pubmed/34421345 http://dx.doi.org/10.7150/ijbs.60866 |
work_keys_str_mv | AT zengbin sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT sunzhiwei sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT zhaoqiting sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT liudoudou sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT chenhao sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT lixiaoshuang sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT xinghrosie sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway AT wangjianyu sec23ainhibitmelanomametastaticthroughsecretorypf4cooperationwithsparctoinhibitmapksignalingpathway |