Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series

PURPOSE: To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum. METHOD: Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) we...

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Autores principales: Wang, Changsong, Kang, Kai, Lan, Xiuwen, Fei, Dongsheng, Wang, Qian, Li, Xianyong, Chong, Yang, Gao, Yan, Wang, Huaiquan, Li, Xueting, Zhao, Mingyan, Yu, Kaijiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Ltd on behalf of The British Infection Association. 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375249/
https://www.ncbi.nlm.nih.gov/pubmed/34419557
http://dx.doi.org/10.1016/j.jinf.2021.08.026
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author Wang, Changsong
Kang, Kai
Lan, Xiuwen
Fei, Dongsheng
Wang, Qian
Li, Xianyong
Chong, Yang
Gao, Yan
Wang, Huaiquan
Li, Xueting
Zhao, Mingyan
Yu, Kaijiang
author_facet Wang, Changsong
Kang, Kai
Lan, Xiuwen
Fei, Dongsheng
Wang, Qian
Li, Xianyong
Chong, Yang
Gao, Yan
Wang, Huaiquan
Li, Xueting
Zhao, Mingyan
Yu, Kaijiang
author_sort Wang, Changsong
collection PubMed
description PURPOSE: To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum. METHOD: Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) were analyzed. RESULTS: Compared with in serum, IL-6 and TNF-α in sputum and in BALF show more directly reflect the severity of COVID-19 critical patients. The gradient ratio of IL-6 levels may predict the prognosis of severe patients. CONCLUSION: Cytokine levels in the sputum may be more helpful for indicating lung damage. Local intervention through the respiratory tract is expected to benefit patients with severe COVID-19.
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spelling pubmed-83752492021-08-19 Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series Wang, Changsong Kang, Kai Lan, Xiuwen Fei, Dongsheng Wang, Qian Li, Xianyong Chong, Yang Gao, Yan Wang, Huaiquan Li, Xueting Zhao, Mingyan Yu, Kaijiang J Infect Letter to the Editor PURPOSE: To describe the relationship between the severity of lung damage and cytokine levels in sputum, bronchoalveolar lavage fluid (BALF), serum. METHOD: Eight severe patients infected with coronavirus disease 2019 (COVID-19) were admitted and their cytokines and chest computed tomography (CT) were analyzed. RESULTS: Compared with in serum, IL-6 and TNF-α in sputum and in BALF show more directly reflect the severity of COVID-19 critical patients. The gradient ratio of IL-6 levels may predict the prognosis of severe patients. CONCLUSION: Cytokine levels in the sputum may be more helpful for indicating lung damage. Local intervention through the respiratory tract is expected to benefit patients with severe COVID-19. Published by Elsevier Ltd on behalf of The British Infection Association. 2021-11 2021-08-19 /pmc/articles/PMC8375249/ /pubmed/34419557 http://dx.doi.org/10.1016/j.jinf.2021.08.026 Text en © 2021 Published by Elsevier Ltd on behalf of The British Infection Association. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
Wang, Changsong
Kang, Kai
Lan, Xiuwen
Fei, Dongsheng
Wang, Qian
Li, Xianyong
Chong, Yang
Gao, Yan
Wang, Huaiquan
Li, Xueting
Zhao, Mingyan
Yu, Kaijiang
Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title_full Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title_fullStr Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title_full_unstemmed Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title_short Cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe COVID-19 – A case series
title_sort cytokine levels in sputum, not serum, may be more helpful for indicating the damage in the lung and the prognosis of severe covid-19 – a case series
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375249/
https://www.ncbi.nlm.nih.gov/pubmed/34419557
http://dx.doi.org/10.1016/j.jinf.2021.08.026
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