Cargando…

Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy

OBJECTIVE: The objective of this study was to examine the relationship between the rate of bilirubin decrease following preoperative biliary drainage before pancreaticoduodenectomy and postoperative morbidity. METHODS: Records of patients who underwent pancreaticoduodenectomy at the Department of Su...

Descripción completa

Detalles Bibliográficos
Autores principales: Rungsakulkij, Narongsak, Thongchai, Varinthip, Suragul, Wikran, Vassanasiri, Watoo, Tangtawee, Pongsatorn, Muangkaew, Paramin, Mingphruedhi, Somkit, Aeesoa, Suraida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375332/
https://www.ncbi.nlm.nih.gov/pubmed/34422273
http://dx.doi.org/10.1177/20503121211039667
_version_ 1783740300151226368
author Rungsakulkij, Narongsak
Thongchai, Varinthip
Suragul, Wikran
Vassanasiri, Watoo
Tangtawee, Pongsatorn
Muangkaew, Paramin
Mingphruedhi, Somkit
Aeesoa, Suraida
author_facet Rungsakulkij, Narongsak
Thongchai, Varinthip
Suragul, Wikran
Vassanasiri, Watoo
Tangtawee, Pongsatorn
Muangkaew, Paramin
Mingphruedhi, Somkit
Aeesoa, Suraida
author_sort Rungsakulkij, Narongsak
collection PubMed
description OBJECTIVE: The objective of this study was to examine the relationship between the rate of bilirubin decrease following preoperative biliary drainage before pancreaticoduodenectomy and postoperative morbidity. METHODS: Records of patients who underwent pancreaticoduodenectomy at the Department of Surgery in Ramathibodi Hospital between January 2008 and December 2019 were retrospectively reviewed. The patients were classified into either an adequate or inadequate drainage rate groups according to the bilirubin decrease rate. Major morbidity was defined as higher than grade II in the Clavien-Dindo classification. Risk factors for major morbidity were analyzed by logistic regression analysis. RESULTS: In total, 166 patients were included in the study. Major morbidity was observed in 36 patients (21.6%). Adequate biliary drainage rate was observed in 39 patients (23.4%). Patients who had major morbidity were less likely to have come from the adequate biliary drainage rate group than the inadequate group (38.9% vs. 61.1%). However, through multivariate logistic analysis, only body mass index, operative time, and pancreatic duct diameter were independent factors associated with major morbidity, whereas the bilirubin decrease rate was not. CONCLUSIONS: Bilirubin decrease rate following preoperative biliary drainage has no significant association with major postoperative morbidity after pancreaticoduodenectomy.
format Online
Article
Text
id pubmed-8375332
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-83753322021-08-20 Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy Rungsakulkij, Narongsak Thongchai, Varinthip Suragul, Wikran Vassanasiri, Watoo Tangtawee, Pongsatorn Muangkaew, Paramin Mingphruedhi, Somkit Aeesoa, Suraida SAGE Open Med Original Research Article OBJECTIVE: The objective of this study was to examine the relationship between the rate of bilirubin decrease following preoperative biliary drainage before pancreaticoduodenectomy and postoperative morbidity. METHODS: Records of patients who underwent pancreaticoduodenectomy at the Department of Surgery in Ramathibodi Hospital between January 2008 and December 2019 were retrospectively reviewed. The patients were classified into either an adequate or inadequate drainage rate groups according to the bilirubin decrease rate. Major morbidity was defined as higher than grade II in the Clavien-Dindo classification. Risk factors for major morbidity were analyzed by logistic regression analysis. RESULTS: In total, 166 patients were included in the study. Major morbidity was observed in 36 patients (21.6%). Adequate biliary drainage rate was observed in 39 patients (23.4%). Patients who had major morbidity were less likely to have come from the adequate biliary drainage rate group than the inadequate group (38.9% vs. 61.1%). However, through multivariate logistic analysis, only body mass index, operative time, and pancreatic duct diameter were independent factors associated with major morbidity, whereas the bilirubin decrease rate was not. CONCLUSIONS: Bilirubin decrease rate following preoperative biliary drainage has no significant association with major postoperative morbidity after pancreaticoduodenectomy. SAGE Publications 2021-08-16 /pmc/articles/PMC8375332/ /pubmed/34422273 http://dx.doi.org/10.1177/20503121211039667 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Rungsakulkij, Narongsak
Thongchai, Varinthip
Suragul, Wikran
Vassanasiri, Watoo
Tangtawee, Pongsatorn
Muangkaew, Paramin
Mingphruedhi, Somkit
Aeesoa, Suraida
Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title_full Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title_fullStr Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title_full_unstemmed Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title_short Association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
title_sort association of the rate of bilirubin decrease with major morbidity in patients undergoing preoperative biliary drainage before pancreaticoduodenectomy
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375332/
https://www.ncbi.nlm.nih.gov/pubmed/34422273
http://dx.doi.org/10.1177/20503121211039667
work_keys_str_mv AT rungsakulkijnarongsak associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT thongchaivarinthip associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT suragulwikran associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT vassanasiriwatoo associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT tangtaweepongsatorn associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT muangkaewparamin associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT mingphruedhisomkit associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy
AT aeesoasuraida associationoftherateofbilirubindecreasewithmajormorbidityinpatientsundergoingpreoperativebiliarydrainagebeforepancreaticoduodenectomy