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Intravenous Immunoglobulin: Revisited – My Experience

BACKGROUND: Many a times while treating dermatoses conventional therapies are either contraindicated or not effective. Intravenous immunoglobulin (IVIG) is a good alternative available to tide over crises. METHOD: Over the last 15 years of my practice I have used IVIg in various severe or recalcitra...

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Autores principales: Vaishampayan, Sanjeev S., Bhati, Surendra Singh, Lachhiramani, Radha R., Shrivastava, Shivank, Jain, Prateek, Raghuwanshi, Ajay Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375533/
https://www.ncbi.nlm.nih.gov/pubmed/34446966
http://dx.doi.org/10.4103/ijd.IJD_559_17
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author Vaishampayan, Sanjeev S.
Bhati, Surendra Singh
Lachhiramani, Radha R.
Shrivastava, Shivank
Jain, Prateek
Raghuwanshi, Ajay Singh
author_facet Vaishampayan, Sanjeev S.
Bhati, Surendra Singh
Lachhiramani, Radha R.
Shrivastava, Shivank
Jain, Prateek
Raghuwanshi, Ajay Singh
author_sort Vaishampayan, Sanjeev S.
collection PubMed
description BACKGROUND: Many a times while treating dermatoses conventional therapies are either contraindicated or not effective. Intravenous immunoglobulin (IVIG) is a good alternative available to tide over crises. METHOD: Over the last 15 years of my practice I have used IVIg in various severe or recalcitrant diseases (including TEN, autoimmune blistering disease,connective tissue disorders , chronic urticaria etc) which were either unresponsive to conventional modality of therapy or primary therapy could not be given because of co-morbidities. RESULT: IVIg a sterile, highly purified preparation containing more than 95% unmodified IgG,was first approved by FDA in 1981 for 6 diseases. As mentioned above in many circumstances we reached a situation when either conventional primary therapy was contraindicated or patients were not responding. IVIg came to our rescue in large number of conditions to tide over the crisis and also created the environment leading to conventional therapy becoming effective. Very few minor side effects like low grade fever and myalgia were observed in very few cases. No serious or severe side effects were seen, however , one has to be prepared for anaphylactic reaction which is a theoretical possibility. CONCLUSION: It can be said that IVIg though not a magic drug, is a very effective tool available in the armamentarium of Dermatologists to treat plethora of chronic and intractable dermatoses.
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spelling pubmed-83755332021-08-25 Intravenous Immunoglobulin: Revisited – My Experience Vaishampayan, Sanjeev S. Bhati, Surendra Singh Lachhiramani, Radha R. Shrivastava, Shivank Jain, Prateek Raghuwanshi, Ajay Singh Indian J Dermatol Original Article BACKGROUND: Many a times while treating dermatoses conventional therapies are either contraindicated or not effective. Intravenous immunoglobulin (IVIG) is a good alternative available to tide over crises. METHOD: Over the last 15 years of my practice I have used IVIg in various severe or recalcitrant diseases (including TEN, autoimmune blistering disease,connective tissue disorders , chronic urticaria etc) which were either unresponsive to conventional modality of therapy or primary therapy could not be given because of co-morbidities. RESULT: IVIg a sterile, highly purified preparation containing more than 95% unmodified IgG,was first approved by FDA in 1981 for 6 diseases. As mentioned above in many circumstances we reached a situation when either conventional primary therapy was contraindicated or patients were not responding. IVIg came to our rescue in large number of conditions to tide over the crisis and also created the environment leading to conventional therapy becoming effective. Very few minor side effects like low grade fever and myalgia were observed in very few cases. No serious or severe side effects were seen, however , one has to be prepared for anaphylactic reaction which is a theoretical possibility. CONCLUSION: It can be said that IVIg though not a magic drug, is a very effective tool available in the armamentarium of Dermatologists to treat plethora of chronic and intractable dermatoses. Wolters Kluwer - Medknow 2021 /pmc/articles/PMC8375533/ /pubmed/34446966 http://dx.doi.org/10.4103/ijd.IJD_559_17 Text en Copyright: © 2021 Indian Journal of Dermatology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Vaishampayan, Sanjeev S.
Bhati, Surendra Singh
Lachhiramani, Radha R.
Shrivastava, Shivank
Jain, Prateek
Raghuwanshi, Ajay Singh
Intravenous Immunoglobulin: Revisited – My Experience
title Intravenous Immunoglobulin: Revisited – My Experience
title_full Intravenous Immunoglobulin: Revisited – My Experience
title_fullStr Intravenous Immunoglobulin: Revisited – My Experience
title_full_unstemmed Intravenous Immunoglobulin: Revisited – My Experience
title_short Intravenous Immunoglobulin: Revisited – My Experience
title_sort intravenous immunoglobulin: revisited – my experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375533/
https://www.ncbi.nlm.nih.gov/pubmed/34446966
http://dx.doi.org/10.4103/ijd.IJD_559_17
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