Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form

In the present study the bioavailability and pharmacokinetics properties of pantoprazole (proton pump inhibitor)/amitriptyline (tricyclic antidepressant) in novel formulated effervescent granules was estimated in rabbit plasma using a validated, selective and rapid LC-MS/MS method. Separation and de...

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Detalles Bibliográficos
Autores principales: El Zaher, Asmaa A., El Kady, Ehab F., EL Messiry, Hussein M., El Ghwas, Hind E., El Houssini, Ola M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375633/
https://www.ncbi.nlm.nih.gov/pubmed/34435144
http://dx.doi.org/10.1016/j.heliyon.2021.e07752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375633/
https://www.ncbi.nlm.nih.gov/pubmed/34435144
http://dx.doi.org/10.1016/j.heliyon.2021.e07752

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