Hospitalization trends and determinants of inpatient costs for eosinophilic esophagitis patients in the United States: results from the Nationwide Inpatient Sample analysis

BACKGROUND: Inpatient care for patients with eosinophilic esophagitis (EoE) is thought to be uncommon, there are few data on inpatient care costs for individuals with EoE. The purpose of this study was to assess trends in inpatient admissions for EoE and examine factors that drive hospitalization costs. METHODS: We examined EoE hospitalizations using ICD-9/10 codes, from 2010-2016 in the National Inpatient Sample. We also identified the diagnosis-related group codes, current procedural terminology codes, and common symptom codes documented during admission. We conducted 2 main analyses, primary (all EoE-related hospitalizations) and secondary (hospitalization with a primary diagnosis for EoE), and a sensitivity analysis using only hospitalizations with the secondary diagnosis for EoE, to determine the trend and cost of EoE-related hospitalizations. We used univariate and multivariate models to evaluate the effect of factors that drive hospitalization on total costs. RESULTS: Our primary analysis showed that an estimated total of 33,467 EoE-related hospitalizations occurred in the US between 2010 and 2016, representing approximately 13 per 100,000 hospitalizations in the US. The admission rate increased by approximately 70% from 2010-2016 (9.26 to 15.75 per 100,000 hospitalizations), while the total annual and mean inflation-adjusted per-patient costs for EoE-related admissions were $24 million per year and $5135 (standard deviation $153), respectively. Patients and hospital characteristics were independently associated with cost of hospitalization. CONCLUSION: The rate of hospital admission for EoE has markedly increased in the US, as has the mean cost for EoE-related hospitalization, at a rate tenfold that of inflation from 2010-2016.