L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but it is unknown whether this effect results from...

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Detalles Bibliográficos
Autores principales: Kuhre, Rune E., Modvig, Ida M., Jepsen, Sara L., Kizilkaya, Hüsün S., Bæch-Laursen, Cecilie, Smith, Christopher A., Reimann, Frank, Gribble, Fiona M., Rosenkilde, Mette M., Holst, Jens J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375664/
https://www.ncbi.nlm.nih.gov/pubmed/34421821
http://dx.doi.org/10.3389/fendo.2021.690387

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