Cargando…
Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study
BACKGROUND: Chronic environmental exposure to manganese (Mn) can cause debilitating damage to the central nervous system. However, its potential toxic effects on the enteric nervous system (ENS) have yet to be assessed. OBJECTIVE: We examined the effect of Mn on the ENS using both cell and animal mo...
Autores principales: | Ghaisas, Shivani, Harischandra, Dilshan S., Palanisamy, Bharathi, Proctor, Alexandra, Jin, Huajun, Dutta, Somak, Sarkar, Souvarish, Langley, Monica, Zenitsky, Gary, Anantharam, Vellareddy, Kanthasamy, Arthi, Phillips, Gregory J., Kanthasamy, Anumantha |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Environmental Health Perspectives
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375672/ https://www.ncbi.nlm.nih.gov/pubmed/34410835 http://dx.doi.org/10.1289/EHP7877 |
Ejemplares similares
-
Manganese-Induced Neurotoxicity: New Insights Into the Triad of Protein Misfolding, Mitochondrial Impairment, and Neuroinflammation
por: Harischandra, Dilshan S., et al.
Publicado: (2019) -
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
por: Sarkar, Souvarish, et al.
Publicado: (2017) -
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
por: Panicker, Nikhil, et al.
Publicado: (2019) -
Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders
por: Padhi, Piyush, et al.
Publicado: (2022) -
PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway
por: Samidurai, Manikandan, et al.
Publicado: (2021)