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Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China

OBJECTIVES: Diabetes mellitus has been associated with stroke. However, the association between fasting blood glucose (FBG) and stroke risk in a general population remains not clear. The purpose of our study was to examine the FBG levels on subsequent stroke risk in a community-based cohort in China...

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Autores principales: Zhang, Ya, Gu, Shujun, Wang, Cuicui, Liu, Dong, Zhang, Qiuyi, Yang, Man, Zhou, Zhengyuan, Zuo, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375728/
https://www.ncbi.nlm.nih.gov/pubmed/34408054
http://dx.doi.org/10.1136/bmjopen-2021-050234
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author Zhang, Ya
Gu, Shujun
Wang, Cuicui
Liu, Dong
Zhang, Qiuyi
Yang, Man
Zhou, Zhengyuan
Zuo, Hui
author_facet Zhang, Ya
Gu, Shujun
Wang, Cuicui
Liu, Dong
Zhang, Qiuyi
Yang, Man
Zhou, Zhengyuan
Zuo, Hui
author_sort Zhang, Ya
collection PubMed
description OBJECTIVES: Diabetes mellitus has been associated with stroke. However, the association between fasting blood glucose (FBG) and stroke risk in a general population remains not clear. The purpose of our study was to examine the FBG levels on subsequent stroke risk in a community-based cohort in China. DESIGN: Prospective cohort study, employing Cox proportional hazard model to analyse the association of FBG levels with stroke risk. SETTING: A community-based cohort study included adults participating in a baseline survey conducted in 2013 in Changshu, eastern China. PARTICIPANTS: 16 113 participants were recruited with a multistage sampling method, excluding participants with severe disability, severe cancer, severe psychiatric disturbance or previous stroke before enrolment. PRIMARY OUTCOME MEASURES: Stroke events. RESULTS: During a median follow-up of 5.5 years, 417 incident cases of stroke were identified. The adjusted HR for total and ischaemic stroke for participants in the fourth quartile of FBG compared with the first quartile was 1.44 (95% CI 1.07 to 1.94) and 1.57 (95% CI 1.11 to 2.21), respectively. FBG levels of ≥7.0 mmol/L were associated with an increased risk of stroke based on two clinical classifications (American Diabetes Association: 1.68 (1.24 to 2.27); WHO: 1.62 (1.21, 2.13)). In stratified analyses, risk associations existed in women (HR: 1.92, 95% CI 1.22 to 3.01) and postmenopausal women (HR: 1.68, 95% CI 1.06 to 2.68) for the fourth quartile versus the first. More importantly, the meta-analysis observed a positive association between FBG levels and stroke risk (pooled HR: 1.70, 95% CI 1.27 to 2.29; n=7)). CONCLUSIONS: Higher FBG level was independently associated with an increased risk of stroke in Chinese adults, especially significant in women.
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spelling pubmed-83757282021-09-02 Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China Zhang, Ya Gu, Shujun Wang, Cuicui Liu, Dong Zhang, Qiuyi Yang, Man Zhou, Zhengyuan Zuo, Hui BMJ Open Public Health OBJECTIVES: Diabetes mellitus has been associated with stroke. However, the association between fasting blood glucose (FBG) and stroke risk in a general population remains not clear. The purpose of our study was to examine the FBG levels on subsequent stroke risk in a community-based cohort in China. DESIGN: Prospective cohort study, employing Cox proportional hazard model to analyse the association of FBG levels with stroke risk. SETTING: A community-based cohort study included adults participating in a baseline survey conducted in 2013 in Changshu, eastern China. PARTICIPANTS: 16 113 participants were recruited with a multistage sampling method, excluding participants with severe disability, severe cancer, severe psychiatric disturbance or previous stroke before enrolment. PRIMARY OUTCOME MEASURES: Stroke events. RESULTS: During a median follow-up of 5.5 years, 417 incident cases of stroke were identified. The adjusted HR for total and ischaemic stroke for participants in the fourth quartile of FBG compared with the first quartile was 1.44 (95% CI 1.07 to 1.94) and 1.57 (95% CI 1.11 to 2.21), respectively. FBG levels of ≥7.0 mmol/L were associated with an increased risk of stroke based on two clinical classifications (American Diabetes Association: 1.68 (1.24 to 2.27); WHO: 1.62 (1.21, 2.13)). In stratified analyses, risk associations existed in women (HR: 1.92, 95% CI 1.22 to 3.01) and postmenopausal women (HR: 1.68, 95% CI 1.06 to 2.68) for the fourth quartile versus the first. More importantly, the meta-analysis observed a positive association between FBG levels and stroke risk (pooled HR: 1.70, 95% CI 1.27 to 2.29; n=7)). CONCLUSIONS: Higher FBG level was independently associated with an increased risk of stroke in Chinese adults, especially significant in women. BMJ Publishing Group 2021-08-18 /pmc/articles/PMC8375728/ /pubmed/34408054 http://dx.doi.org/10.1136/bmjopen-2021-050234 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Public Health
Zhang, Ya
Gu, Shujun
Wang, Cuicui
Liu, Dong
Zhang, Qiuyi
Yang, Man
Zhou, Zhengyuan
Zuo, Hui
Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title_full Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title_fullStr Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title_full_unstemmed Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title_short Association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from China
title_sort association between fasting blood glucose levels and stroke events: a large-scale community-based cohort study from china
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375728/
https://www.ncbi.nlm.nih.gov/pubmed/34408054
http://dx.doi.org/10.1136/bmjopen-2021-050234
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