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Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study

CONTEXT: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surg...

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Autores principales: Deepak, T. A., Manjunath, M., Thakur, Harshita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375818/
https://www.ncbi.nlm.nih.gov/pubmed/34447150
http://dx.doi.org/10.4103/jpbs.JPBS_687_20
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author Deepak, T. A.
Manjunath, M.
Thakur, Harshita
author_facet Deepak, T. A.
Manjunath, M.
Thakur, Harshita
author_sort Deepak, T. A.
collection PubMed
description CONTEXT: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surgical therapy, and physiotherapy, has been attempted till date, with varying degrees of benefit. AIMS: The objective of this study was to assess efficacy of curcumin for the treatment of OSMF; to asses efficacy of topical steroids for the treatment of OSMF; and to compare the efficacy of curcumin and topical steroid for the treatment of OSMF. SETTING AND DESIGN: Participants were assessed based subjective and objective feature of OSMF, i.e., burning sensation of the oral cavity and interincisal distance, respectively. METHODOLOGY: Thirty participants were categorized into two groups: Group A was administered curcumin and Group B was administered topical steroids for a period of 3 months and followed up after 6 months. The assessment was based on maximal incisal opening and burning sensation for spicy food on Visual Analog Scale score. ANALYSIS: Independent t test was applied for comparison within the group, ANOVA Bonferroni post hoc test was applied for multiple comparison of mean and Mann–Whitney U test was applied to compare the groups. RESULTS: The statistical analysis revealed curcumin to be more efficient than topical steroid. CONCLUSION: The present study demonstrates the efficiency of curcumin and topical steroid to alleviate the clinical findings of OSMF. However, curcumin is comparatively more efficient than steroids for the treatment of OSMF.
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spelling pubmed-83758182021-08-25 Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study Deepak, T. A. Manjunath, M. Thakur, Harshita J Pharm Bioallied Sci Original Article CONTEXT: Oral submucous fibrosis (OSMF) is a chronic debilitating disease of the oral cavity, characterized by inflammation and progressive fibrosis of the submucosal tissues. The main agent involved in the pathogenesis of OSMF is areca nut. A wide range of treatment, including drug management, surgical therapy, and physiotherapy, has been attempted till date, with varying degrees of benefit. AIMS: The objective of this study was to assess efficacy of curcumin for the treatment of OSMF; to asses efficacy of topical steroids for the treatment of OSMF; and to compare the efficacy of curcumin and topical steroid for the treatment of OSMF. SETTING AND DESIGN: Participants were assessed based subjective and objective feature of OSMF, i.e., burning sensation of the oral cavity and interincisal distance, respectively. METHODOLOGY: Thirty participants were categorized into two groups: Group A was administered curcumin and Group B was administered topical steroids for a period of 3 months and followed up after 6 months. The assessment was based on maximal incisal opening and burning sensation for spicy food on Visual Analog Scale score. ANALYSIS: Independent t test was applied for comparison within the group, ANOVA Bonferroni post hoc test was applied for multiple comparison of mean and Mann–Whitney U test was applied to compare the groups. RESULTS: The statistical analysis revealed curcumin to be more efficient than topical steroid. CONCLUSION: The present study demonstrates the efficiency of curcumin and topical steroid to alleviate the clinical findings of OSMF. However, curcumin is comparatively more efficient than steroids for the treatment of OSMF. Wolters Kluwer - Medknow 2021-06 2021-06-05 /pmc/articles/PMC8375818/ /pubmed/34447150 http://dx.doi.org/10.4103/jpbs.JPBS_687_20 Text en Copyright: © 2021 Journal of Pharmacy and Bioallied Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Deepak, T. A.
Manjunath, M.
Thakur, Harshita
Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title_full Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title_fullStr Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title_full_unstemmed Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title_short Efficacy of Curcumin and Topical Steroids in the Treatment for Oral Submucous Fibrosis: A Comparative study
title_sort efficacy of curcumin and topical steroids in the treatment for oral submucous fibrosis: a comparative study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375818/
https://www.ncbi.nlm.nih.gov/pubmed/34447150
http://dx.doi.org/10.4103/jpbs.JPBS_687_20
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AT thakurharshita efficacyofcurcuminandtopicalsteroidsinthetreatmentfororalsubmucousfibrosisacomparativestudy