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Nano-hydroxyapatite: A Driving Force for Bone Tissue Engineering

Bone is an amazing nanocomposite tissue made of both organic (primarily collagen) and inorganic (primarily nano-hydroxyapatite [n-HA]) elements. Bone grafting is a widely used surgical technique in dental and orthopedic surgeries to enhance bone regeneration. In view of the significant drawbacks of...

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Detalles Bibliográficos
Autores principales: Rajula, M. Prem Blaisie, Narayanan, Vivek, Venkatasubbu, G. Devanand, Mani, Rekha Chandra, Sujana, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375893/
https://www.ncbi.nlm.nih.gov/pubmed/34447034
http://dx.doi.org/10.4103/jpbs.JPBS_683_20
Descripción
Sumario:Bone is an amazing nanocomposite tissue made of both organic (primarily collagen) and inorganic (primarily nano-hydroxyapatite [n-HA]) elements. Bone grafting is a widely used surgical technique in dental and orthopedic surgeries to enhance bone regeneration. In view of the significant drawbacks of traditional treatments, nanomaterials offer new strategies for bone regeneration. The HA with the chemical formula of Ca(10)(OH) (2)(PO4) (6) is very identical to the inorganic portion of bone. Due to its high stability and minimal solubility, it is often used in orthopedic and dental procedures. Currently, n-HA, which facilitates the growth of new bone, has garnered considerable attention because of better bioactivity and bone integration ability when compared to porous HA. This review gives comprehensive insights related to n-HA structure, chemical composition, surface modification techniques, and their application in bone tissue engineering.