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Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer

BACKGROUND: Although low skeletal muscle mass has an adverse impact on the treatment outcomes of cancer patients, whether the relationship between preoperative skeletal muscle mass and gastrectomy outcomes in gastric cancer (GC) differs between men and women is unclear. The study aimed to clarify th...

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Autores principales: Sakurai, Katsunobu, Kubo, Naoshi, Tamamori, Yutaka, Aomatsu, Naoki, Nishii, Takafumi, Tachimori, Akiko, Nishiguchi, Yukio, Maeda, Kiyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375973/
https://www.ncbi.nlm.nih.gov/pubmed/34411190
http://dx.doi.org/10.1371/journal.pone.0256365
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author Sakurai, Katsunobu
Kubo, Naoshi
Tamamori, Yutaka
Aomatsu, Naoki
Nishii, Takafumi
Tachimori, Akiko
Nishiguchi, Yukio
Maeda, Kiyoshi
author_facet Sakurai, Katsunobu
Kubo, Naoshi
Tamamori, Yutaka
Aomatsu, Naoki
Nishii, Takafumi
Tachimori, Akiko
Nishiguchi, Yukio
Maeda, Kiyoshi
author_sort Sakurai, Katsunobu
collection PubMed
description BACKGROUND: Although low skeletal muscle mass has an adverse impact on the treatment outcomes of cancer patients, whether the relationship between preoperative skeletal muscle mass and gastrectomy outcomes in gastric cancer (GC) differs between men and women is unclear. The study aimed to clarify this relationship based on gender. METHODS: Between January 2007 and December 2015, 1054 patients who underwent gastrectomy for GC at Osaka City General Hospital were enrolled in this study. We evaluated sarcopenia by the skeletal muscle index (SMI), which was measured by computed tomography (CT) using areas of muscle in the third lumbar vertebral body (L3). Male and female patients were each divided into two groups (low skeletal muscle and high skeletal muscle). RESULTS: The SMI emerged as an independent predictor of 5-year overall survival (OS) in male GC patients (Hazard ratio 2.51; 95% confidence interval (CI) 1.73–3.63, p < 0.001) based on multivariate analysis. However, this index was not an independent predictive determinant of 5-year cancer-specific survival (CSS). The SMI was not an independent predictor of either OS or CSS in female GC patients. The incidence of leakage and major complication (Clavien Dindo grade ≧ 3) did not differ significantly across groups. CONCLUSIONS: Preoperative skeletal muscle mass is a valuable prognostic predictor of OS in male GC patients.
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spelling pubmed-83759732021-08-20 Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer Sakurai, Katsunobu Kubo, Naoshi Tamamori, Yutaka Aomatsu, Naoki Nishii, Takafumi Tachimori, Akiko Nishiguchi, Yukio Maeda, Kiyoshi PLoS One Research Article BACKGROUND: Although low skeletal muscle mass has an adverse impact on the treatment outcomes of cancer patients, whether the relationship between preoperative skeletal muscle mass and gastrectomy outcomes in gastric cancer (GC) differs between men and women is unclear. The study aimed to clarify this relationship based on gender. METHODS: Between January 2007 and December 2015, 1054 patients who underwent gastrectomy for GC at Osaka City General Hospital were enrolled in this study. We evaluated sarcopenia by the skeletal muscle index (SMI), which was measured by computed tomography (CT) using areas of muscle in the third lumbar vertebral body (L3). Male and female patients were each divided into two groups (low skeletal muscle and high skeletal muscle). RESULTS: The SMI emerged as an independent predictor of 5-year overall survival (OS) in male GC patients (Hazard ratio 2.51; 95% confidence interval (CI) 1.73–3.63, p < 0.001) based on multivariate analysis. However, this index was not an independent predictive determinant of 5-year cancer-specific survival (CSS). The SMI was not an independent predictor of either OS or CSS in female GC patients. The incidence of leakage and major complication (Clavien Dindo grade ≧ 3) did not differ significantly across groups. CONCLUSIONS: Preoperative skeletal muscle mass is a valuable prognostic predictor of OS in male GC patients. Public Library of Science 2021-08-19 /pmc/articles/PMC8375973/ /pubmed/34411190 http://dx.doi.org/10.1371/journal.pone.0256365 Text en © 2021 Sakurai et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sakurai, Katsunobu
Kubo, Naoshi
Tamamori, Yutaka
Aomatsu, Naoki
Nishii, Takafumi
Tachimori, Akiko
Nishiguchi, Yukio
Maeda, Kiyoshi
Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title_full Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title_fullStr Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title_full_unstemmed Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title_short Depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
title_sort depletion of skeletal muscle mass adversely affects long-term outcomes for men undergoing gastrectomy for gastric cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375973/
https://www.ncbi.nlm.nih.gov/pubmed/34411190
http://dx.doi.org/10.1371/journal.pone.0256365
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