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An application of the ensemble Kalman filter in epidemiological modelling

Since the novel coronavirus (COVID-19) outbreak in China, and due to the open accessibility of COVID-19 data, several researchers and modellers revisited the classical epidemiological models to evaluate their practical applicability. While mathematical compartmental models can predict various contag...

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Detalles Bibliográficos
Autores principales: Lal, Rajnesh, Huang, Weidong, Li, Zhenquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376003/
https://www.ncbi.nlm.nih.gov/pubmed/34411132
http://dx.doi.org/10.1371/journal.pone.0256227
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author Lal, Rajnesh
Huang, Weidong
Li, Zhenquan
author_facet Lal, Rajnesh
Huang, Weidong
Li, Zhenquan
author_sort Lal, Rajnesh
collection PubMed
description Since the novel coronavirus (COVID-19) outbreak in China, and due to the open accessibility of COVID-19 data, several researchers and modellers revisited the classical epidemiological models to evaluate their practical applicability. While mathematical compartmental models can predict various contagious viruses’ dynamics, their efficiency depends on the model parameters. Recently, several parameter estimation methods have been proposed for different models. In this study, we evaluated the Ensemble Kalman filter’s performance (EnKF) in the estimation of time-varying model parameters with synthetic data and the real COVID-19 data of Hubei province, China. Contrary to the previous works, in the current study, the effect of damping factors on an augmented EnKF is studied. An augmented EnKF algorithm is provided, and we present how the filter performs in estimating models using uncertain observational (reported) data. Results obtained confirm that the augumented-EnKF approach can provide reliable model parameter estimates. Additionally, there was a good fit of profiles between model simulation and the reported COVID-19 data confirming the possibility of using the augmented-EnKF approach for reliable model parameter estimation.
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spelling pubmed-83760032021-08-20 An application of the ensemble Kalman filter in epidemiological modelling Lal, Rajnesh Huang, Weidong Li, Zhenquan PLoS One Research Article Since the novel coronavirus (COVID-19) outbreak in China, and due to the open accessibility of COVID-19 data, several researchers and modellers revisited the classical epidemiological models to evaluate their practical applicability. While mathematical compartmental models can predict various contagious viruses’ dynamics, their efficiency depends on the model parameters. Recently, several parameter estimation methods have been proposed for different models. In this study, we evaluated the Ensemble Kalman filter’s performance (EnKF) in the estimation of time-varying model parameters with synthetic data and the real COVID-19 data of Hubei province, China. Contrary to the previous works, in the current study, the effect of damping factors on an augmented EnKF is studied. An augmented EnKF algorithm is provided, and we present how the filter performs in estimating models using uncertain observational (reported) data. Results obtained confirm that the augumented-EnKF approach can provide reliable model parameter estimates. Additionally, there was a good fit of profiles between model simulation and the reported COVID-19 data confirming the possibility of using the augmented-EnKF approach for reliable model parameter estimation. Public Library of Science 2021-08-19 /pmc/articles/PMC8376003/ /pubmed/34411132 http://dx.doi.org/10.1371/journal.pone.0256227 Text en © 2021 Lal et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lal, Rajnesh
Huang, Weidong
Li, Zhenquan
An application of the ensemble Kalman filter in epidemiological modelling
title An application of the ensemble Kalman filter in epidemiological modelling
title_full An application of the ensemble Kalman filter in epidemiological modelling
title_fullStr An application of the ensemble Kalman filter in epidemiological modelling
title_full_unstemmed An application of the ensemble Kalman filter in epidemiological modelling
title_short An application of the ensemble Kalman filter in epidemiological modelling
title_sort application of the ensemble kalman filter in epidemiological modelling
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376003/
https://www.ncbi.nlm.nih.gov/pubmed/34411132
http://dx.doi.org/10.1371/journal.pone.0256227
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